Nitric oxide-mediated vasodilation increases blood flow during the early stages of stress fracture healing

Journal of Applied Physiology
Ryan E TomlinsonMatthew J Silva

Abstract

Despite the strong connection between angiogenesis and osteogenesis in skeletal repair conditions such as fracture and distraction osteogenesis, little is known about the vascular requirements for bone formation after repetitive mechanical loading. Here, established protocols of damaging (stress fracture) and nondamaging (physiological) forelimb loading in the adult rat were used to stimulate either woven or lamellar bone formation, respectively. Positron emission tomography was used to evaluate blood flow and fluoride kinetics at the site of bone formation. In the group that received damaging mechanical loading leading to woven bone formation (WBF), (15)O water (blood) flow rate was significantly increased on day 0 and remained elevated 14 days after loading, whereas (18)F fluoride uptake peaked 7 days after loading. In the group that received nondamaging mechanical loading leading to lamellar bone formation (LBF), (15)O water and (18)F fluoride flow rates in loaded limbs were not significantly different from nonloaded limbs at any time point. The early increase in blood flow rate after WBF loading was associated with local vasodilation. In addition, Nos2 expression in mast cells was increased in WBF-, but not LBF-, loaded lim...Continue Reading

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Citations

Mar 20, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ryan E TomlinsonMatthew J Silva
Aug 15, 2015·Bone Research·David UlmertDaniel Lj Thorek
Dec 25, 2015·British Journal of Sports Medicine·Cyril MartinPhilippe Connes
May 8, 2018·Medicinal Research Reviews·Harshika AwasthiAtul Gupta
Feb 5, 2021·Frontiers in Bioengineering and Biotechnology·Albert Thomas AnastasioJoseph S Fernandez-Moure

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