PMID: 8951939Oct 1, 1996Paper

Nitric oxide mediates long-term hyperalgesic and antinociceptive effects of the N-terminus of substance P in the formalin assay in mice

Pain
V M Goettl, A A Larson

Abstract

Conditions such as hyperalgesia can occur days or months after the noxious insult. Substance P (SP) is released in response to noxious stimuli. Given the long-term effects of the N-terminus of SP on putative nociceptive transmitters, we investigated changes in formalin-induced nociception following an accumulation of SP N-terminal metabolites in mice. Pre-treatment with the N-terminal metabolite of SP, SP(1-7), was without effect when injected intrathecally (i.t.) 5 or 30 min before formalin. However, at 24 h, SP(1-7) increased behaviors during Phase 1, indicating hyperalgesia, and attenuated Phase 2 responses, consistent with antinociception. The nitric oxide (NO) synthase inhibitor, N omega-nitro-L-arginine methyl ester HCl (L-NAME), blocked both hyperalgesic and antinociceptive effects when co-injected with SP(1-7). Consistent with a NO-mediated pathway, L-arginine (L-arg), the N-terminal amino acid of SP and precursor to NO, mimicked the antinociceptive effect of SP(1-7) on Phase 2. The hyperalgesic effect of SP(1-7) in Phase 1, which was not mimicked by L-arg, was prevented by D-SP(1-7), a SP(1-7) antagonist. Thus, SP(1-7) modulates nociception via two distinct NO-mediated pathways. When injected for 7 days, tolerance deve...Continue Reading

References

Feb 25, 1992·European Journal of Pharmacology·J NäsströmC Post
Apr 1, 1991·Journal of the Autonomic Nervous System·C A Maggi
Jan 1, 1991·British Journal of Pharmacology·P K MooreS L Hart
Apr 1, 1988·Brain Research Bulletin·R A Cridland, J L Henry
Jul 1, 1989·Pain·M Nakamura-Craig, T W Smith
Mar 1, 1985·Journal of Neurochemistry·T SakuradaL Terenius
Sep 1, 1982·Peptides·J M StewartW A Krivoy
Jan 1, 1983·Peptides·M E Hall, J M Stewart
Jun 23, 1994·European Journal of Pharmacology·V M GoettlZ Wiesenfeld-Hallin

❮ Previous
Next ❯

Citations

Nov 18, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Marie-Françoise DoursoutJacques E Chelly
May 15, 2002·European Journal of Pharmacology·Wiliam A PradoFernando Q Cunha
Mar 29, 2001·Behavioural Brain Research·I P BarettaT C De Lima
Jun 19, 2010·Progress in Neurobiology·Jun Chen, William R Lariviere
Aug 21, 2007·European Journal of Pain : EJP·Shailesh P DudhgaonkarV Ravi Prakash
May 17, 2000·The Journal of Pharmacy and Pharmacology·Y H ParkU D Sohn
Jun 21, 2006·Vascular Pharmacology·Aaron VinikJagdeesh Ullal
Nov 3, 2010·The Journal of Pharmacology and Experimental Therapeutics·Kent T SymonsTadimeti S Rao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.