PMID: 8592181Nov 1, 1995Paper

Nitric oxide mediates the inhibitory effects of SDPNFLRFamide, a nematode FMRFamide-related neuropeptide, in Ascaris suum

Journal of Neurophysiology
J W BowmanT G Geary

Abstract

1. The physiological effects of two Phe-Met-Arg-Phe-NH2 (FMRFamide)-related neuropeptides isolated from the free-living nematode Panagrellus redivivus, SDPNFLRFamide (PF1) and SADPNFLRFamide (PF2), were examined using neuromuscular preparations from the parasitic nematode Ascaris suum. 2. PF1 and PF2 hyperpolarized muscle membrane and induced sustained flaccid paralysis, independent of external Cl-, in both innervated and denervated preparations. 3. PF1 reversed spastic contractions induced by the cholinomimetic levamisole, elevated K+, or the excitatory nematode FMRFamide-related neuropeptides KNEFIRFamide or KHEYLRFamide. 4. PF1 reversal of levamisole contraction was blocked by pretreatment with agents that interfere with nitric oxide (NO) synthesis (e.g., N-nitro-L-arginine), whereas sodium nitroprusside, which releases NO in solution, mimicked PF1 and PF2. 5. NO synthase activity, monitored by the conversion of [3H]arginine to [3H]citrulline, was twice as abundant in A. suum hypodermis as in muscle, but was not present in reproductive tissue. The relative abundance of NO synthase activity in these tissues was similar to the observed specific binding of [3H]PF1. 6. These results suggest that the inhibitory effects of PF1 and...Continue Reading

Citations

Jan 1, 1996·Parasitology·D P ThompsonT G Geary
Jun 1, 1997·Invertebrate Neuroscience : in·J W Jacklet
Sep 6, 2002·Journal of Veterinary Pharmacology and Therapeutics·Erich W ZinserTimothy G Geary
Mar 2, 2010·Invertebrate Neuroscience : in·Robert J WalkerLindy Holden-Dye
Jul 24, 2018·Parasite Immunology·Rosângela Maria RodriguesJulia Maria Costa-Cruz
Oct 16, 1999·Nature·D M MinningJ S Stamler
Mar 26, 2004·The Journal of Parasitology·Wei ZhuGeorge B Stefano
Oct 30, 2014·Frontiers in Endocrinology·Chris Li, Kyuhyung Kim
Feb 17, 2000·Annals of the New York Academy of Sciences·T G GearyD P Thompson
Oct 22, 2009·Journal of Helminthology·M J G JohnstonA G Maule
Feb 20, 2010·Journal of Biomedicine & Biotechnology·Antonio Muro, José-Luís Pérez-Arellano
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y GoumonG B Stefano
Jul 16, 2002·International Journal for Parasitology·Michael J KimberAaron G Maule
Apr 8, 2006·International Journal for Parasitology·Paul McVeighAaron G Maule
Jul 11, 2006·Trends in Parasitology·Paul McVeighAaron G Maule
Dec 27, 2007·Archives of Biochemistry and Biophysics·Muneaki HashimotoTakashi Aoki
Sep 2, 2008·International Journal for Parasitology·S VermaR J Martin

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