Nitric oxide metabolites and arginase I levels in β-thalassemic patients: an Egyptian study.

Annals of Hematology
Samy B M El-HadyMohammad A Elhady

Abstract

Stored red blood cells become deficient in nitric oxide that limits their ability to transfer oxygen to tissues that need it. The aims of this study are to assess the endogenous nitric oxide metabolites (NOx) and arginase I levels in transfusion-dependent β-thalassemic patients; to compare these levels in patients transfused with fresh RBCs with patients transfused with old RBCs, β-thalassemic minor patients, and normal control; and to correlate these levels with some clinical variables. Group I was composed of 23 patients with homozygous β-thalassemia on hypertransfusion regimen. They were adequately transfused with fresh RBC. Group II was composed of 17 patients with homozygous β-thalassemia on hypertransfusion regimen. They were adequately transfused with old RBCs. Group III was composed of 30 patients with homozygous β-thalassemia. They were adequately transfused with fresh RBCs. Group IV was composed of 18 patients with homozygous β-thalassemia. They were adequately transfused with old RBCs. Both group III and group IV were supposed to be on hypertransfusion regimen, but they did not follow the regimen. Group V was composed of 21 patients of β-thalassemia minor. Nineteen apparently healthy individuals (HbAA) served as a co...Continue Reading

References

Feb 1, 1992·Pediatrics in Review·P J Giardina, M W Hilgartner
Jan 1, 1974·Annals of the New York Academy of Sciences·S PiomelliW J Kuhns
Jun 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·E AziziK Wallis
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y XiaJ L Zweier
Nov 10, 1998·The Biochemical Journal·G Wu, S M Morris
Jan 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·S I Zharikov, E R Block
Jun 11, 2002·Annual Review of Nutrition·Sidney M Morris
Jun 27, 2002·Molecular Genetics and Metabolism·Phillip S KimWayne W Grody
Nov 12, 2002·Nature Medicine·Christopher D ReiterMark T Gladwin
Feb 27, 2004·The New England Journal of Medicine·Elliott P Vichinsky
Jul 7, 2005·JAMA : the Journal of the American Medical Association·Claudia R MorrisMark T Gladwin
Sep 16, 2005·The New England Journal of Medicine·Deborah Rund, Eliezer Rachmilewitz
Dec 1, 2005·Pediatric Blood & Cancer·Rahul NaithaniShashi Narayan
Dec 13, 2005·Annals of the New York Academy of Sciences·Claudia R MorrisElliott P Vichinsky
Apr 29, 2006·British Journal of Haematology·R W HagarE P Vichinsky
Jul 1, 2006·Acta Haematologica·G PiattiM D Cappellini
Apr 25, 2007·Pediatric Hematology and Oncology·Gregory J KatoMark T Gladwin
Oct 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Elliott Bennett-GuerreroTimothy J McMahon
Oct 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·James D ReynoldsJonathan S Stamler
Dec 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Joseph Bonaventura
Nov 11, 2008·Current Molecular Medicine·Claudia R MorrisGregory J Kato
Oct 15, 2010·Free Radical Research·Keiki OginoDa-Hong Wang
Apr 19, 2011·Transfusion·Daniel B Kim-ShapiroMark T Gladwin

❮ Previous
Next ❯

Citations

Apr 16, 2013·Haematologica·Claudia R MorrisUNKNOWN Thalassemia Clinical Research Network
Apr 25, 2015·British Journal of Haematology·Claudia R MorrisUNKNOWN Thalassemia Clinical Research Network
Feb 24, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Azza A G TantawyShereen H Aly
Jul 23, 2013·The American Journal of Clinical Nutrition·Francesco Saverio Dioguardi
Sep 22, 2016·Antioxidants & Redox Signaling·Rhoda Elison HirschJoel M Friedman
May 6, 2017·International Journal of Hematology·Sudarat SatitthummanidSuphot Srimahachota

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.