Nitric oxide modulates anoxia-induced gasping in the developing rat

Biology of the Neonate
D GozalP J Hornby

Abstract

Gasping is an important mechanism for survival. Nitric oxide (NO) plays an excitatory role in brainstem regions mediating respiratory responses to hypoxia. We hypothesized that neural structures mediating anoxia-induced gasping would display NO dependency. Two- to 15-day-old rat pups underwent anoxic exposures with 100% N2 in a plethysmograph following administration of N-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase (NOS) blocker, L-arginine (L-Arg), a NO precursor, or normal saline. In general, gasp latencies were significantly shorter after L-Arg, and were prolonged with L-NAME. Furthermore, NOS inhibition prolonged gasping duration and reduced gasping frequency at all postnatal ages, although this effect was particularly increased with advancing postnatal age. NADPH-diaphorase staining and Western blots of protein lysates from the lateral tegmental field, the putative neural center underlying gasp generation, revealed progressively increased neuronal NOS abundance with animal maturation. We conclude that anoxia-induced gasping neurogenesis is modulated by NO mechanisms in neonatal pups. We postulate that higher NO brainstem concentrations may favor early autoresuscitation but be detrimental to overall surv...Continue Reading

Citations

Jun 9, 2005·Respiratory Physiology & Neurobiology·James E Fewell
Jul 21, 1999·Journal of the Autonomic Nervous System·D A RuggieroA L Sica
Sep 27, 2003·The European Journal of Neuroscience·Fabrice ChatonnetArthur S Foutz
Apr 19, 2008·Journal of Applied Physiology·Bradley T Thach
Feb 14, 2009·Journal of Applied Physiology·Jeffery T Erickson, Brian C Sposato
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Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A Sener, F G Smith
Nov 15, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sulleman S Malik, James E Fewell
Mar 29, 2001·Journal of Neuropathology and Experimental Neurology·J MansouriH C Kinney
Feb 14, 2002·Journal of Applied Physiology·David GozalAndrew J Lipton
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J E FewellY Wang

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