Nitric oxide modulates in vivo and in vitro growth hormone release in acromegaly

Neuroendocrinology
C M CutticaG Giordano

Abstract

Nitric oxide (NO) has recently been shown to modulate pituitary secretion both in vivo and in vitro. The aim of this study was to investigate the effects of this chemical transmitter on spontaneous and growth-hormone-releasing hormone (GHRH)-induced growth hormone (GH) secretion in acromegalic patients, as well as from GH-secreting tumors maintained in vitro. The study was carried out in 7 acromegalic patients (46.2 +/- 2 years) and in 5 normal subjects (40.1 +/- 1.5 years). GH and prolactin (PRL) secretion were assayed during the administration of isosorbide dinitrate (ID, 5 mg, orally), an NO donor, GHRH, and ID plus GHRH. During ID, a significant (p < 0.05) increase (37%) over basal GH levels was only observed in acromegalics. There was no change in GH levels in response to GHRH or ID plus GHRH in either group. No significant change in PRL levels was observed in either group during ID, while GHRH, with or without ID, induced a slight increase in PRL levels in acromegalics only. Tumor specimens were obtained by selective transsphenoidal adenomectomy, and the cells were plated and incubated for 1, 2 and 24 h in the presence of sodium nitroprusside, a releaser of NO (SNP, 0.3 or 0.6 mM), of GHRH (10-8 M) or of both. SNP signifi...Continue Reading

Citations

Feb 18, 1999·Molecular and Cellular Endocrinology·B H DuvilanskiD Becu-Villalobos
Apr 30, 2010·BMC Medical Genomics·Xianquan Zhan, Dominic M Desiderio
Dec 30, 2014·BMC Medical Genomics·Xianquan ZhanDominic M Desiderio
Mar 28, 2013·Oxidative Medicine and Cellular Longevity·Xianquan ZhanDominic M Desiderio
Nov 14, 2012·Environmental Toxicology and Pharmacology·Xiaoyu HuangGuoyuan Chen
Aug 30, 2005·Blood Pressure·Vanessa RonconiLaura Mazzanti

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