PMID: 9525554Apr 3, 1998Paper

Nitric oxide modulation of neutrophil-endothelium interaction: difference between arterial and venous coronary bypass grafts

Journal of the American College of Cardiology
M ChelloA Colonna

Abstract

This study sought to evaluate the relation between the pattern of neutrophil-endothelial adhesion in saphenous vein (SV) and internal mammary artery (IMA) grafts and the endothelial production of nitric oxide (NO). Autologous IMA and SV grafts (SVGs) are increasingly used as conduits for coronary bypass grafting. Previous studies have demonstrated a greater production of endothelial-derived relaxing factor (NO) from IMA than from SVGs. Because of the well known role of NO in modulating the adhesion of polymorphonuclear leukocytes to the endothelium, we studied the pattern of neutrophil adhesion to the endothelium of IMA and SVs under basal conditions and after inhibition of NO synthesis. Segments of IMA and SVs were obtained from 20 patients undergoing coronary artery bypass graft surgery. We evaluated the adhesion of both unstimulated and activated neutrophils to the endothelial surface of IMA and SVs in both basal conditions and after inhibition of NO synthesis with Nomega-nitro-L-arginine methyl ester. Under basal conditions, no difference in unstimulated neutrophil adhesion to endothelium was observed between the two vessel conduits. After neutrophil activation, a significantly (p < 0.05) greater adhesion of neutrophils was...Continue Reading

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Citations

Mar 29, 2000·The Annals of Thoracic Surgery·T V Bilfinger, G B Stefano
Mar 5, 2009·Antioxidants & Redox Signaling·Gregor Muller, Henning Morawietz
Mar 1, 2006·Critical Care Medicine·Massimo ChelloElvio Covino
May 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Naoki IsobeShigeru Oshima
Dec 12, 2012·The Journal of Thoracic and Cardiovascular Surgery·Paul A ChecchiaCharles B Huddleston
Jul 25, 2006·International Journal of Cardiology·Gerasimos SiasosChristodoulos Stefanadis
May 17, 2003·Circulation Research·Jan Rupp, Matthias Maass
Feb 4, 2003·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Hendrick B Barner
Jan 30, 2003·Vascular Medicine·Dimitris TousoulisPavios Toutouzas
Jul 11, 2020·World Journal for Pediatric & Congenital Heart Surgery·Chawki ElzeinLuca Vricella
Apr 9, 2004·Journal of Vascular Surgery·Joseph NanobashviliTadeusz Malinski

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