Nitric oxide. Novel biology with clinical relevance

Annals of Surgery
T R Billiar

Abstract

The author provides the reader with a view of the regulation and function of nitric oxide (NO), based on the three distinct enzyme isoforms that synthesize NO. Nitric oxide is a short-lived molecule exhibiting functions as diverse as neurotransmission and microbial killing. Recent advances in the characterization of the enzymes responsible for NO synthesis and in the understanding of how NO interacts with targets have led to new insights into the many facets of this diverse molecule. Nitric oxide is produced by one of three enzyme isoforms of NO synthesis. These enzymes vary considerably in their distribution, regulation, and function. Accordingly, the NO synthesis or lack of NO production will have consequences unique to that isoform. Therefore, this review summarizes the regulation and function of NO generated by each of the three isoforms. Nitric oxide exhibits many unique characteristics that allow this molecule to perform so many functions. The amount, duration, and location of the NO synthesis will depend on the isoform of NO synthase expressed. For each isoform, there probably are disease processes in which deficiency states exist. For induced NO synthesis, states of overexpression exist. Understanding the regulation and...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S WilcoxH H Schmidt
Jan 1, 1992·The Journal of Clinical Investigation·J H ChinB B Hoffman
Nov 1, 1992·The Journal of Clinical Investigation·P J Shultz, L Raij
Jan 1, 1992·Neuron·D S Bredt, S H Snyder
Jul 1, 1992·The Journal of Experimental Medicine·A K NusslerR L Simmons
Jul 17, 1992·Science·A L BurnettS H Snyder
Aug 20, 1992·The New England Journal of Medicine·J M VanderwindenM H De Laet
Aug 1, 1992·The Journal of Experimental Medicine·H J ChoC Nathan
Nov 1, 1992·Critical Care Medicine·B G HarbrechtR L Simmons
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T NguyenS R Tannenbaum
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·V L DawsonS H Snyder
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Dec 4, 1990·European Journal of Pharmacology·N K Boughton-SmithS Moncada
Nov 15, 1990·Biochemical and Biophysical Research Communications·R G KilbournR F Lodato
Jul 5, 1990·The New England Journal of Medicine·J A PanzaS E Epstein
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Jun 1, 1988·British Journal of Pharmacology·W DuranteF A Sunahara
Apr 1, 1988·The Journal of Clinical Investigation·D L GrangerD T Durack
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D J Stuehr, M A Marletta
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H M Abu-Soud, D J Stuehr
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S CeccatelliT Hökfelt
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·I G CharlesS Moncada
Feb 1, 1994·Archives of Surgery·F M RobertsonB A Pruitt
Nov 1, 1993·European Journal of Clinical Investigation·F MearinJ R Malagelada
Jan 1, 1993·American Journal of Surgery·H S KaufmanK D Lillemoe
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C ThiemermannJ R Vane

❮ Previous
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Citations

Jun 11, 1999·International Journal of Cancer. Journal International Du Cancer·A OrucevicP K Lala
Jul 15, 1998·Arthritis and Rheumatism·R M ClancyS B Abramson
Aug 6, 2008·Annals of Hematology·Gülsüm Emel PamukNesibe Yeşil
Jul 24, 2010·Journal of Physiology and Biochemistry·Mohamed A HaidaraEsma R Isenovic
Sep 1, 1996·The Annals of Thoracic Surgery·E D Verrier, E M Boyle
Nov 4, 1998·The Annals of Thoracic Surgery·W R BurfeindD Samuelson
Feb 1, 1997·Transplantation Proceedings·P T van SuylichemR J Ploeg
Sep 2, 1998·Transplantation Proceedings·A R MuellerP Neuhaus
Sep 10, 2003·Journal of Ethnopharmacology·Celil UsluFatih Akcay
Oct 22, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jelka GabrilovacAna Andreis
Sep 18, 1999·Free Radical Biology & Medicine·A MülschM A Foster
Jul 31, 1998·Nutrition·D EvoyJ M Daly
May 29, 2002·Bioorganic & Medicinal Chemistry Letters·Jeremiah J HarnettPierre-E Chabrier
Sep 25, 1999·Bioorganic & Medicinal Chemistry Letters·J A LoweM Stefaniak
May 23, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·L M SutherlandA W Murray
Jun 3, 2006·Natural Product Reports·Tara L PukalaMichael J Tyler
Mar 10, 2001·Antioxidants & Redox Signaling·C M PayneH Garewal
Oct 13, 2006·Current Opinion in Gastroenterology·R N Dubois
Oct 1, 1996·Plastic and Reconstructive Surgery·T C LimH E Khoo
Mar 17, 1999·Plastic and Reconstructive Surgery·D G MeldrumW A Zamboni
Jul 22, 2006·Annals of Surgery·Andreas TürlerAnthony J Bauer
Feb 6, 2004·Clinical and Experimental Pharmacology & Physiology·Gursev S Dhaunsi, Pinar T Ozand
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·M D Maines
Oct 6, 1997·The Journal of Clinical Investigation·C ZaragozaC J Lowenstein
Oct 28, 1998·Environmental Health Perspectives·N S Shah, T R Billiar
Feb 24, 2004·Biological Chemistry·Peter K M KimTimothy R Billiar
Dec 26, 2008·World Journal of Gastroenterology : WJG·Tie-Cheng YangAi-Min Ren
Aug 29, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Tomas KuceraJindrich Martinek

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