PMID: 9538311Apr 16, 1998Paper

Nitric oxide, oxygen, and prostacyclin in children with pulmonary hypertension

Heart
M I TuranlahtiE Pesonen

Abstract

To test the vasodilatory response of the pulmonary vascular bed in children with pulmonary hypertension. Prospective dose response study in which the effects of inhaled nitric oxide (NO) are compared with those of oxygen and intravenous prostacyclin. The vasodilator test was performed in 20 patients in whom mean pulmonary artery pressure (PAPm) was > or = 40 mm Hg and /or pulmonary vascular resistance index was > or = 4 Um2. Haemodynamic effects of inhaled NO (20, 40, and 80 ppm) at a fractional inspired oxygen (FiO2) value of 0.3, pure oxygen, oxygen at FiO2 0.9-1.0 combined with NO as above or with intravenous prostacyclin at 10 and 20 ng/kg/min were measured. NO decreased PAPm with a dose response from 20 to 40 ppm (mean change at 40 ppm-5.50, 95% confidence interval (CI) -7.98 to -3.02 mm Hg. Maximal decrease in the ratio of pulmonary to systemic vascular resistance was achieved with a combination of NO 80 ppm and oxygen (-0.18, 95% CI -0.26 to -0.10). Increase in the pulmonary flow index was greatest with pure oxygen in those with an intracardiac shunt (8.52, 95% CI -0.15 to 17.20 l/min/m2). Neither NO nor oxygen altered systemic arterial pressure but intravenous prostacyclin lowered systemic arterial pressure and resistan...Continue Reading

Citations

Jan 11, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·E Dumas de la RoqueS Bonnet
Jan 27, 2007·Journal of Cardiovascular Medicine·Andrea DontiFernando M Picchio
May 9, 2009·Cardiology in the Young·Antonio A Lopes, Patrick W O'Leary
May 18, 2000·Scandinavian Cardiovascular Journal : SCJ·M I TuranlahtiE J Pesonen
Jul 8, 2000·The Journal of Thoracic and Cardiovascular Surgery·M BousamraC A Dawson
Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·Pierre WauthySerge Brimioulle
Apr 25, 2018·Circulation·Bradley S MarinoUNKNOWN American Heart Association Congenital Cardiac Defects Committee of the Council on Cardiovascular Disease in the Young; Counc
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Mar 27, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Christian von SchnakenburgChristoph Fink

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