PMID: 9534943Apr 16, 1998Paper

Nitric oxide participates in the corpus luteum regression in ovaries isolated from pseudopregnant rats

Canadian Journal of Physiology and Pharmacology
A B Motta, M F Gimeno

Abstract

In previous reports we found that nitric oxide is involved in corpus luteum regression in the rat by increasing prostaglandin F2 alpha synthesis during the luteolytic phase. In the present study we were interested in determining whether nitric oxide synthase activity is modulated with the corpus luteum development. For this purpose ovarian tissues obtained from pseudopregnant rats at different stages of pseudopregnancy, early, middle, and late, were used. Working with different doses of two competitive nitric oxide synthase inhibitors, NG-monomethyl-L-arginine (L-NMMA) and aminoguanidine (AG), we investigated the possible role of endogenous nitric oxide in the regulation of prostaglandin F2 alpha production by rat ovaries in the three different phases mentioned. We found that nitric oxide synthase activity diminishes with the corpus luteum development and that the calcium-independent activity was the predominant form of this enzyme in all stages studied. Endogenous nitric oxide increased prostaglandin F2 alpha synthesis only during the late phase of the corpus luteum. In the study of the possible role of nitric oxide regulating ovarian steroidogenesis, we found that L-NMMA increased progesterone production and diminished prosta...Continue Reading

Citations

May 12, 2004·Nitric Oxide : Biology and Chemistry·A EstévezA B Motta
Nov 24, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S M McCannW H Yu
Mar 14, 2002·Molecular Reproduction and Development·Se-Jin YoonKyung-Ah Lee

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