Nitric oxide production during Eimeria tenella infections in chickens

Poultry Science
P C Allen

Abstract

The objective of this study was to gather evidence for production of nitric oxide (NO) during a primary infection with the protozoan parasite Eimeria tenella, which carries out its life cycle in the ceca of chickens. Relationships of plasma levels of NO2(-)+NO3-, stable metabolites of NO, with parasite dose and with time after infection were examined, as well as effects of administration of aminoguanidine, an inhibitor of induced nitric oxide synthase (iNOS). Inoculation with 5 x 10(4) and 1 x 10(6) but not 1 x 10(3) oocysts per chick caused significant (P < or = 0.05) increases in micromolar concentrations of plasma NO3(-)+NO3- when measured at 7 d postinoculation (PI). In chickens inoculated with 5 x 10(4) oocysts, significant (P < or = 0.05) increases in plasma NO2(-)+NO3- were seen at 5 and 7 but not 3 d PI. Daily intraperitoneal administration of 1.25 mg per chick aminoguanidine during the period of infection did not lower the increases in plasma NO2(-)+NO3- seen at 5 and 7 d PI, and did not affect the degree of colonization of the cecal tissue by the parasite. However, administration of aminoguanidine did alter the gross appearance of the ceca, which were less swollen and filled with blood at 5 and 7 d PI as compared with...Continue Reading

Citations

Aug 14, 2010·Avian Pathology : Journal of the W.V.P.A·Guangxing LiGregory R Siragusa
Jul 14, 2010·Comparative Immunology, Microbiology and Infectious Diseases·Kyung-Woo LeeGregory R Siragusa
Oct 2, 2012·Experimental Parasitology·Coraline BichetGabriele Sorci
Jul 20, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Thangarasu MuthamilselvanWen-Chin Yang
Sep 17, 2010·Die Naturwissenschaften·Clotilde BiardJérôme Moreau
Oct 28, 2011·The Veterinary Quarterly·H W Peek, W J M Landman
Jan 7, 1998·Immunological Reviews·P C DohertyP G Stevenson
Oct 14, 2019·Parasitology Research·Saeed A El-AshramKhaled T Abdelaziz
Apr 14, 2004·Avian Diseases·B VermeulenW J M Landman
Mar 19, 2021·Journal of Animal Science and Biotechnology·Bochen SongYuming Guo
May 16, 2017·Research in Veterinary Science·Pieter de GouwHenry van den Brand

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