Nitric oxide pros and cons: The role of L-arginine, a nitric oxide precursor, and idebenone, a coenzyme-Q analogue in ameliorating cerebral hypoxia in rat

Brain Research Bulletin
Nayira A Abdel BakyHazar Yaqub

Abstract

Evidence exists that nitric oxide (NO) may mediate both protective and pathological responses during brain hypoxia (HP). Reactive oxygen species have also been implicated in the pathophysiological response of the brain tissues to HP. Therefore, this study investigated whether a NO precursor, l-arginine (l-arg), a free radical scavenger, idebenone (ID), and their combination would reduce neurological injury resulting from hemic hypoxia (HP) in rats. Adult male Wistar albino rats were injected with sodium nitrite (60 mg/kg, s.c.) to establish hemic hypoxia. ID (100 mg kg(-1), i.p.) and/or l-arg (100 mg kg(-1), i.p.) were administrated 24 and 1h prior to sodium nitrite intoxication, respectively. Hypoxia significantly decreased hemoglobin concentration, while significantly increased serum lactate dehydrogenase (LDH), creatine phosphokinase (CPK), total nitrate/nitrite, sialic, and uric acids concentrations. Moreover, brain lipid peroxides were significantly enhanced, while reduced glutathione, l-ascorbic acids, adenosine triphosphate (ATP) contents, and the activities of catalase and superoxide dismutase, were significantly reduced in the brain tissue. Pretreatment with either ID or l-arg altered the majority of the above-mentione...Continue Reading

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Citations

Aug 9, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jung Hyun KwakJong Ho Lee
Jul 23, 2013·Journal of Neuroimmunology·Sebastian M FiebigerCarmen Infante-Duarte
Jul 16, 2014·Pharmaceutical Biology·Dhas JebasinghBright Starling Emerald
Nov 22, 2018·Reproduction in Domestic Animals = Zuchthygiene·Mohsen EslamiFarhad Farrokhi-Ardabili
Apr 18, 2020·Journal of Food Biochemistry·Nermin Abdel Hamid SadikHager Abd Al-Hamid
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Aug 17, 2012·Molecular Pharmaceutics·Lucia MontenegroMaria Grazia Sarpietro

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