Nitric oxide reduces organ injury and enhances regeneration of reduced-size livers by increasing hepatic arterial flow

The British Journal of Surgery
Daniel CantréChristian Eipel

Abstract

Reduced-size livers suffer from portal hyperperfusion, diminished arterial blood flow and the risk of postoperative liver injury. The aim of this experimental study was to unravel the role of nitric oxide in this setting. Rats underwent 85 per cent partial hepatectomy and either substitution of nitric oxide with molsidomine or inhibition of nitric oxide synthase (NOS) with N(G)-nitro-L-arginine methyl ester. Untreated hepatectomized animals served as controls and unresected animals as the sham group. Ultrasonic flowmetry following partial hepatectomy revealed a marked increase in portal venous inflow with a concomitant decrease in hepatic arterial inflow. Nitric oxide substitution counteracted the decline in hepatic arterial inflow and caused a significantly greater increase in cell proliferation after partial hepatectomy compared with control or NOS-inhibited animals. Hepatectomized animals further profited from nitric oxide substitution, as indicated by reduced aminotransferase release and improved liver function. Nitric oxide improves the postoperative course of rats with reduced-size livers by modulating hepatic macrohaemodynamics and mediating regeneration and cytoprotection, but not by reducing hepatic hyperperfusion and ...Continue Reading

References

Dec 1, 1972·Biorheology·J F Gross, J Aroesty
Apr 4, 1997·Science·G K Michalopoulos, M C DeFrances
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S YoshiokaY Fukuda
May 18, 1999·The American Journal of Physiology·M T WheelerS J Swoap
Jun 10, 2000·The British Journal of Surgery·Y ShimizuN Nakajima
Nov 18, 2000·Proceedings of the Society for Experimental Biology and Medicine·T Yamamoto, R J Bing
Oct 6, 2001·Nitric Oxide : Biology and Chemistry·J M SchoenW W Lautt
Feb 28, 2003·World Journal of Surgery·Michael J GoldsteinJean C Emond
Jun 5, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Chung-Mau LoSheung-Tat Fan
Aug 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Tetsuya KiuchiKohei Ogawa
Jan 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·C EipelB Vollmar
Jan 11, 2005·World Journal of Gastroenterology : WJG·Hafize UzunSafiye Kaya
Feb 25, 2005·Annals of Surgery·Christian EipelBrigitte Vollmar
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Roberto TroisiBernard de Hemptinne
Jun 24, 2005·American Journal of Surgery·Emma J MullinGuy J Maddern
Jul 14, 2005·Virchows Archiv : an International Journal of Pathology·Daniel PalmesHans-Ullrich Spiegel
Oct 11, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Felix DahmPierre-Alain Clavien
Dec 2, 2005·Langenbeck's Archives of Surgery·Hiroshi ShimadaShinji Togo
Jan 10, 2006·Seminars in Oncology·Jean-Nicolas VautheyTimothy M Pawlik
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nelson FaustoKimberly J Riehle
Feb 9, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M GlanemannP Neuhaus
Mar 21, 2006·Journal of Hepato-biliary-pancreatic Surgery·Rafik Mark Ghobrial, Ronald W Busuttil
Jul 25, 2006·The American Journal of Surgical Pathology·Anthony J DemetrisAmadeo Marcos
Aug 16, 2006·Transplantation Proceedings·E C TolentinoO Feres
Sep 29, 2006·Transplantation·Sheung Tat Fan
Oct 19, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·T NobuokaK Hirata
Apr 3, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Harald SchuettBrigitte Vollmar
Jul 4, 2007·Surgical Oncology Clinics of North America·Renato LupinacciBernard Nordlinger

❮ Previous
Next ❯

Citations

Feb 9, 2012·Langenbeck's Archives of Surgery·Kerstin AbshagenBrigitte Vollmar
Nov 20, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nicolas GolseEric Vibert
Apr 28, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·U ShergillV H Shah
Dec 25, 2010·World Journal of Gastroenterology : WJG·Christian EipelBrigitte Vollmar
May 21, 2014·Microvascular Research·Jan NilssonChristian Sturesson
Jun 2, 2012·World Journal of Surgical Oncology·Tsuyoshi KurokawaSatoru Sugiyama
Oct 21, 2011·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·C EipelB Vollmar
Jan 17, 2016·Tissue Engineering. Part C, Methods·Pedro M BaptistaShay Soker
Jan 22, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kenya YamanakaShinji Uemoto
May 10, 2013·ANZ Journal of Surgery·José G TralhãoFrancisco Castro-Sousa
Mar 17, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maximilian von HeesenMohammed R Moussavian
Nov 28, 2012·Nutrition Research·Ryan T HurtPaul J Matheson
Oct 12, 2016·Scientific Reports·Jorge CarrapitaJorge Maciel Barbosa
May 18, 2017·Transplantation·Jean C EmondRobert M Merion
Oct 11, 2019·World Journal of Hepatology·Paul CarrierVéronique Loustaud-Ratti
Jun 20, 2020·Digestive Diseases and Sciences·Toru Goto, Markus Selzner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Laura Pezzuto, H Glenn Bohlen
Current Opinion in Gastroenterology
Robert F Grimble
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Antonio F CornoLudwig K von Segesser
© 2022 Meta ULC. All rights reserved