PMID: 8614554Nov 17, 1995Paper

Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats

Neuroscience Letters
J SegiethP S Whitton

Abstract

The effect of altering hippocampal nitric oxide levels on basal and N-methyl-D-aspartate (NMDA) receptor-evoked release of glutamate and aspartate has been studied in freely moving rats. NMDA increased extracellular glutamate and aspartate in a concentration-dependent manner. The nitric oxide synthase inhibitor L-nitro-arginine-methyl ester (L-NAME; 100 microM) increased basal glutamate and aspartate release, and also enhanced release of these amino acids evoked by NMDA (100 microM) compared with the same concentration of NMDA infused alone. L-NAME at 200 microM increased basal dialysate glutamate, but not aspartate, to a lesser extent than the 100 microM concentration of the drug, and the NMDA-induced release of glutamate and aspartate was decreased. L-NAME at 1.0 mM did not significantly alter basal extracellular glutamate but significantly decreased dialysate aspartate, while abolishing the NMDA-evoked release of both amino acids. The actions of L-NAME were not mimicked by its much less active isomer D-nitro-arginine-methyl ester. The nitric oxide donor drug S-nitroso-N-penicillamine decreased dialysate glutamate and aspartate at a 500 microM concentration but increased the extracellular level of both amino acids when infuse...Continue Reading

References

Apr 1, 1992·Journal of Neurochemistry·P S WhittonL J Fowler
Sep 22, 1992·European Journal of Pharmacology·G LonartK M Johnson
Feb 1, 1991·Trends in Neurosciences·J Garthwaite
Jul 9, 1991·European Journal of Pharmacology·G A BöhmeJ C Blanchard
Jan 12, 1994·Neuroreport·O BugnonM Schorderet
Mar 28, 1994·Neuroscience Letters·E PrzegalińskiJ Siwanowicz

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Citations

Jun 9, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jin-Tae HongKi-Wan Oh
Jul 23, 1999·Brain Research·S T KaehlerA Philippu
Jan 27, 2000·Respiration Physiology·B HoopH Kazemi
May 14, 2003·Neurochemistry International·Pirjo Saransaari, Simo S Oja
Jun 17, 2000·Progress in Neurobiology·S S Oja, P Saransaari
Mar 16, 2001·Progress in Neurobiology·H Prast, A Philippu
May 30, 1997·Neuroscience Letters·A N Katchman, N Hershkowitz
May 15, 1998·General Pharmacology·E A Del BelF S Guimarães
Apr 21, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·T ArakiY Itoyama
Jan 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Takeshi IshideAhmmed Ally
Feb 15, 1997·Environmental Toxicology and Pharmacology·Y B KimS Shin
Oct 26, 2005·Neuropsychobiology·M A RichardsonJames D Clelland
Jul 14, 2007·European Journal of Pharmacology·Nikolaos Pitsikas, Nikolaos Sakellaridis
Sep 23, 2014·Stress : the International Journal on the Biology of Stress·Hsiao-Jou Cortina ChenNickolas A Lavidis
Jul 25, 2009·The International Journal of Neuropsychopharmacology·Gregers WegenerBetina Elfving
Aug 1, 1997·Nitric Oxide : Biology and Chemistry·S M SequeiraC M Carvalho
Jul 11, 2008·Critical Reviews in Toxicology·Edward J Calabrese
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese, L A Baldwin

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