Nitric Oxide Regulates The Lymphatic Reactivity Following Hemorrhagic Shock Through Atp-Sensitive Potassium Channel

Shock
Li-Min ZhangChun-Yu Niu

Abstract

Lymphatic reactivity has been shown to exhibit a biphasic change following hemorrhagic shock, and nitric oxide (NO) is involved in this process. However, the precise mechanism responsible for NO regulation of the lymphatic reactivity along with the progression of hemorrhagic shock is unclear. Therefore, the present study was to investigate how NO participates in regulating the shock-induced biphasic changes in lymphatic reactivity and its underlying mechanisms. First, the expressions or contents of inducible NO synthase, nitrite plus nitrate, and elements of cAMP-PKA-KATP and cGMP-PKG-KATP pathway in thoracic ducts tissue were assessed. The results revealed that levels of nitrite plus nitrate, cAMP, cyclic guanosine monophosphate (cGMP), p-PKA, and p-PKG were increased gradually along with the process of shock. Second, the roles of cAMP-PKA-KATP and cGMP-PKG-KATP in NO regulating lymphatic response to gradient substance P were evaluated with an isolated lymphatic perfusion system. The results showed that the NOS substrate (L-Arg), PKA donor (8-Br-cAMP) decreased the reactivity of shock 0.5 h-lymphatics, and that the PKA inhibitor (H-89) and KATP inhibitor (glibenclamide) restrained the effects of L-Arg while glibenclamide aboli...Continue Reading

References

Aug 15, 1997·The Journal of Physiology·K D CottonK D Thornbury
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·P Y von der WeidD F Van Helden
May 29, 2003·British Journal of Pharmacology·Alice K Chan, Pierre-Yves von der Weid
Dec 25, 2003·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Takayuki MatsumotoKatsuo Kamata
Aug 10, 2004·The Journal of Experimental Biology·Klaus Ballanyi
Apr 5, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·William F Jackson
Jul 1, 2006·The Journal of Physiology·Olga Yu GashevaAnatoliy A Gashev
Jul 1, 2006·Journal of Cardiovascular Pharmacology·Guangming YangTao Li
Aug 22, 2007·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Rongzhen ZhangMichael J Davis
Jun 4, 2008·Annals of the New York Academy of Sciences·Mariappan Muthuchamy, David Zawieja
Nov 26, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Michael J DavisAnatoliy A Gashev
Jun 16, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Wei WangMariappan Muthuchamy
Aug 12, 2009·American Journal of Physiology. Heart and Circulatory Physiology·H Glenn BohlenDave Zawieja
Jul 17, 2013·Shock·Frank HildebrandMartijn van Griensven
Apr 30, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Niklas TeliniusDonna Briggs Boedtkjer

❮ Previous
Next ❯

Citations

May 18, 2016·Shock·Mark G Clemens
Aug 21, 2021·Cardiovascular Research·Peter S RussellAnthony R J Phillips

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Bin GengJunbao Du
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Li-Min ZhangYu-Ping Zhang
© 2022 Meta ULC. All rights reserved