Nitric oxide regulation of myocardial O2 consumption and HEP metabolism

American Journal of Physiology. Heart and Circulatory Physiology
Jianyi ZhangR J Bache

Abstract

NO and O(2) compete at cytochrome-c oxidase, thus potentially allowing NO to modulate mitochondrial respiration. We previously observed a decrease of myocardial phosphocreatine (PCr)/ATP during very high cardiac work states, corresponding to an increase in cytosolic free ADP. This study tested the hypothesis that NO inhibition of respiration contributes to this increase of ADP. Infusion of dobutamine + dopamine (DbDp, each 20 microg.kg(-1).min(-1) iv) to more than double myocardial oxygen consumption (MVo(2)) in open-chest dogs caused a decrease of myocardial PCr/ATP measured with (31)P NMR from 2.04 +/- 0.09 to 1.85 +/- 0.08 (P < 0.05). Inhibition of NO synthesis with N(omega)-nitro-L-arginine (L-NNA), while catecholamine infusion continued, caused PCr/ATP to increase to the control value. In a second group of animals, L-NNA administered before catecholamine stimulation (reverse intervention of the first group) increased PCr/ATP during basal conditions. In these animals L-NNA did not prevent a decrease of PCr/ATP at the high cardiac work state but, relative to MVo(2), PCr/ATP was significantly higher after L-NNA. In a third group of animals, pharmacological coronary vasodilation with carbochromen was used to prevent changes in...Continue Reading

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Citations

Apr 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Fan WuDaniel A Beard
Aug 2, 2007·Antioxidants & Redox Signaling·Fernando AntunesEnrique Cadenas
Aug 29, 2009·PLoS Computational Biology·Daniel A Beard, Martin J Kushmerick
Aug 1, 2015·Physiological Reports·Kenneth TranEdmund J Crampin
Nov 11, 2006·Journal of Magnetic Resonance Imaging : JMRI·Joseph LeeJianyi Zhang
Sep 1, 2007·Journal of Applied Physiology·Bradley J BehnkeTimothy I Musch
Dec 21, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Daniel A Beard

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