Abstract
We investigated the influence of endothelial nitric oxide (NO) on the pulmonary pressor activity of the stable thromboxane A2 analogue, U-46619 (9,11-dideoxy-9 alpha-(methanoepoxy) prostaglandin F2 alpha), in anesthetized open-chest Sprague-Dawley rats (n = 6-9 per group). NO synthase inhibition, as obtained by N omega-nitro-L-arginine methyl ester (L-NAME; 0.63 mg/kg i.v. + 20 mg/kg/h), induced sustained systemic hypertension (mean maximal increase, delta, in mean systemic arterial pressure = 38 +/- 6 mmHg; P < 0.05 vs. vehicle) associated with slight bradycardia (delta heart rate = -42 +/- 8 beats/min; P < 0.05 vs. vehicle) and delayed- (> 30 min) onset pulmonary hypertension (delta mean pulmonary arterial pressure = 10 +/- 3.4 mmHg; P < 0.05 vs. vehicle). In separate experiments, when mean systemic arterial pressure was maximally increased by L-NAME, the difference between mean pulmonary arterial pressure and mean left atrial pressure was greater in L-NAME-treated rats (41 +/- 16% compared to 10 +/- 1% in the vehicle group; P < 0.05), strongly suggesting that spontaneously released NO modulated pulmonary vascular resistance. L-Arginine at a dose which reduced by approximately 50% the L-NAME-associated systemic hypertension d...Continue Reading
References
Mar 17, 1992·European Journal of Pharmacology·B D NossamanP J Kadowitz
Mar 3, 1992·European Journal of Pharmacology·K Y ChyuG Ross
Feb 1, 1992·Hypertension·Y X WangH Gavras
May 30, 1991·The New England Journal of Medicine·A T Dinh-XuanJ Wallwork
Jun 1, 1991·Circulation·C FrostellW M Zapol
Aug 21, 1990·European Journal of Pharmacology·N P WiklundP Hedqvist
May 1, 1990·Hypertension·S M GardinerS Moncada
Jun 1, 1990·Hypertension·V LaheraJ C Romero
Jul 1, 1990·British Journal of Pharmacology·M G PerssonS Moncada
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
Jan 1, 1987·Circulation Research·L J IgnarroK S Wood
Jan 1, 1985·The American Journal of Cardiology·M McGregor, A Sniderman
Jan 1, 1981·Peptides·H L LipptonP J Kadowitz
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jan 1, 1994·Journal of Cardiovascular Pharmacology·P A VanderfordJ R Fineman
May 1, 1994·Circulation·J S StamlerM A Creager
Jan 1, 1995·Critical Care Medicine·A D KayeP J Kadowitz
Jul 27, 1995·The New England Journal of Medicine·A Giaid, D Saleh
Apr 1, 1995·British Journal of Pharmacology·Y X WangC C Pang
May 1, 1995·British Journal of Pharmacology·F BertolinoF C Colpaert
Jan 19, 1995·The American Journal of Cardiology·L J Rubin
Jun 1, 1993·Anesthesiology·D P NyhanP A Murray
Jan 15, 1996·Circulation·C J CooperA P Selwyn
Jul 15, 2011·Pharmacological Reviews·D F WoodwardS Narumiya
Citations
Feb 12, 1998·British Journal of Pharmacology·G W John, J P Valentin
Mar 7, 1998·British Journal of Pharmacology·F PagniezG W John
Feb 24, 2007·Veterinary Anaesthesia and Analgesia·Francisco J Teixeira NetoConstanza S Nogueira
May 14, 2016·Canadian Journal of Physiology and Pharmacology·Edward A PankeyPhilip J Kadowitz
Aug 5, 2000·American Journal of Physiology. Renal Physiology·C G SchnackenbergC S Wilcox