PMID: 9188768Jan 1, 1997Paper

Nitric oxide regulatory role in sensitized guinea pig trachea

Life Sciences
B D'agostinoF Rossi

Abstract

Nitric oxide (NO) has been cited to play an important regulatory role in airway function. Moreover, the NO synthase expression in models of inflammation is documented. The aim of this study was to investigate, in vitro, the NO modulation of cholinergic responses in sham-sensitized and ovalbumin-sensitized guinea pig trachea by using L-arginine (L-ARG), a precursor of NO synthesis, and L-Ng-nitro-arginine-methyl-ester (L-NAME), an inhibitor of NO synthase. Our results showed that NO's ability to modulate cholinergic responses in ovalbumin-sensitized guinea pig trachea is lost. Indeed L-ARG and L-NAME modify acetylcholine sensitivity in sham-sensitized guinea pig but not in ovalbumin-sensitized guinea pig.

References

Jul 1, 1992·The American Review of Respiratory Disease·T R HsiueJ Solway
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J S PollockF Murad
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J R VaneD A Willoughby
May 1, 1995·International Archives of Allergy and Immunology·B J UndemA C Myers
Jan 15, 1994·Lancet·S A KharitonovP J Barnes

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