Nitric oxide relaxes bovine ciliary muscle contracted by carbachol through elevation of cyclic GMP

Experimental Eye Research
S KamikawatokoH Azuma

Abstract

It is generally accepted that nitric oxide relaxes vascular smooth muscles by activating guanylyl cyclase, which in turn increases cyclic 3':5' guanosine monophosphate level. Despite the physiological significance of nitric oxide, very few studies have attempted to characterize the mode of action of this mediator in ciliary muscles. Therefore, the present experiments were designed to investigate whether or not the relaxation induced by sodium nitroprusside as a donor of nitric oxide is accompanied by the increase in cyclic 3':5' guanosine monophosphate level in the bovine ciliary muscle, and these responses are affected by methylene blue as an inhibitor of guanylyl cyclase and 3-isobutyl-1-methylxanthine as an inhibitor of phosphodiesterases. The relaxation activity of exogenous 8-bromo-cyclic 3':5' guanosine monophosphate was also determined. Sodium nitroprusside produced a concentration-dependent relaxation in the bovine ciliary muscle strips which had been contracted by carbachol as a cholinergic agonist. Relaxation in response to sodium nitroprusside was accompanied by a significant (P<0.05 and P<0.005) increase in cyclic 3':5' guanosine monophosphate level. The relaxation response and the increase in cyclic 3':5' guanosine...Continue Reading

References

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Citations

Apr 28, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·G C Chiou
Apr 27, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·C BeauregardG C Chiou
Sep 11, 2003·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·J C Millar
Jun 27, 2013·Investigative Ophthalmology & Visual Science·Galen W HeyneB'Ann T Gabelt
Dec 15, 2010·Experimental Eye Research·B'Ann T GabeltCarol A Rasmussen
May 26, 2015·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Minori IshidaAkira Takai
Jun 7, 2014·Frontiers in Molecular Neuroscience·Emmanuel S BuysBruce R Ksander
Oct 28, 2003·Journal of Pharmacological Sciences·Iwao Katsuyama, Tsutomu Arakawa
Sep 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuri NomiHitoshi Matsumoto
Jul 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jaeyong KimChulyung Choi
Jul 28, 1999·European Journal of Pharmacology·M C Koss

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