Nitric oxide release from kidneys of hypertensive rats treated with imidapril

Hypertension
Y HirataM Omata

Abstract

To examine whether endothelial dysfunction in hypertension is reversible or not, we studied the effects of imidapril, an angiotensin-converting enzyme inhibitor, on nitric oxide release in stroke-prone spontaneously hypertensive rats (SHR) and deoxycorticosterone acetate (DOCA)-salt hypertensive rats. After a 4-week treatment with imidapril (1 or 10 mg/d SC) or vehicle, acetylcholine-induced vasodilation and nitric oxide release in the isolated kidneys were determined. Nitric oxide release was measured by a chemiluminescense assay. Imidapril lowered blood pressure in stroke-prone SHR in a dose-dependent manner. Untreated stroke-prone SHR exhibited significantly attenuated responses to acetylcholine (10(-8) mol/L) of both renal perfusion pressure (stroke-prone SHE 42 +/- 4% versus Wistar-Kyoto rats [WKY] 58 +/- 4% [mean +/- SE], P < .01) and nitric oxide release (stroke-prone SHR +7.6 +/- 2.1 versus WKY +29.7 +/- 9.7 fmol/min per gram of kidney wt, P < .01). Imidapril at 10 mg/d significantly increased acetylcholine-induced renal vasodilation and nitric oxide release in stroke-prone SHR (renal perfusion pressure, 56 +/- 3%; nitric oxide release, +27.1 +/- 6.4 fmol/min per gram of kidney wt; both P < .01 versus stroke-prone SHR t...Continue Reading

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Citations

Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tsuguru HattaMasao Nakagawa
Jun 1, 2000·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·K ShimamuraS Sunano
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Oct 12, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rajesh Choudhary, Surendra H Bodakhe
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Dec 4, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Qiming ShaoNaranjan S Dhalla
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Jul 24, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Satoru Sunano, Fumiko Sekiguchi
Aug 15, 2002·Cardiovascular Drug Reviews·Kazuyoshi Hosoya, Toshihiko Ishimitsu

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