Nitric oxide-releasing polymer incorporated ointment for cutaneous wound healing

Journal of Controlled Release : Official Journal of the Controlled Release Society
Youngnam KangWon Jong Kim

Abstract

This work demonstrates the development of nitric oxide-releasing ointment and its potential on efficient wound healing. Nitric oxide-releasing polymer was successfully synthesized, which is composed of biocompatible Pluronic F127, branched polyethylenimine and 1-substituted diazen-1-ium-1,2-diolates. The synthesized nitric oxide-releasing polymer was incorporated into the PEG-based ointment which not only facilitated nitric oxide release in a slow manner, but also served as a moisturizer to enhance the wound healing. As compared to control groups, the nitric oxide-releasing ointment showed the accelerated wound closure with enhanced re-epithelialization, collagen deposition, and blood vessel formation in vivo. Therefore, this nitric oxide-based ointment presents the promising potential for the efficient strategy to heal the cutaneous wound.

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Citations

Jan 16, 2019·Advanced Healthcare Materials·Maggie J Malone-PovolnyMark H Schoenfisch
Apr 25, 2020·Journal of Tissue Engineering and Regenerative Medicine·Valéria C O PóvoaMarcelo G de Oliveira
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Jul 3, 2021·International Journal of Molecular Sciences·Yan-Cheng LiouYang-Chang Wu
May 15, 2019·Nano Letters·Jiwon YeoWon Jong Kim

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