Abstract
A perforated-patch whole-cell recording method was used to determine whether nitric oxide signaling participates in acetylcholine (ACh)-induced regulation of basal L-type Ca2+ current (ICa,L) in cat atrial myocytes. Exposure to 1 microM ACh for 2 min inhibited basal ICa,L (-21 +/- 3%), and withdrawal of ACh elicited rebound stimulation of ICa,L above control (80 +/- 13%) (n = 23). Stimulation of ICa,L elicited by withdrawal of ACh (but not ACh-induced inhibition of ICa,L) was blocked by either 50 microM hemoglobin; 30 microM ODQ or 10 microM methylene blue, inhibitors of soluble guanylate cyclase; 10 microM W-7, a calmodulin inhibitor; or 10 microM L-NIO, an inhibitor of constitutive NO synthase (NOS). In cells incubated in 5 mM L-arginine, ACh-induced rebound stimulation of ICa,L was enhanced compared with control responses. Histochemical assay (NADPH diaphorase) indicated that atrial myocytes express constitutive NOS. NO-donor, spermine/NO (SP/NO), >1 microM stimulated basal ICa,L. SP/NO-induced stimulation of ICa,L was inhibited by 50 microM hemoglobin, 30 microM ODQ, or 5 microM H-89, an inhibitor of PKA, and was unchanged by 50 microM MnTBAP, a peroxynitrite scavenger. When ICa,L was prestimulated by 10 microM milrinone, a...Continue Reading
References
Dec 18, 1992·Science·J S StamlerJ Loscalzo
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J S StamlerJ Loscalzo
Feb 1, 1991·The Journal of Clinical Investigation·D BeasleyB M Brenner
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P F MéryR Fischmeister
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B T HopeS R Vincent
Nov 1, 1991·Journal of Medicinal Chemistry·C M MaragosL K Keefer
Aug 1, 1987·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J Linden
Aug 1, 1988·The Journal of General Physiology·R Horn, A Marty
Jan 1, 1984·The Japanese Journal of Physiology·T Ehara, T Mitsuiye
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·H HidakaT Nagata
Jul 1, 1995·The Journal of General Physiology·X HanW R Giles
Mar 1, 1994·Pflügers Archiv : European journal of physiology·R C LeviM P Gallo
Jan 1, 1995·The American Journal of Physiology·G M Wahler, S J Dollinger
Jun 16, 1995·The Journal of Biological Chemistry·J L BalligandT Michel
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J L BalligandT Michel
Jun 1, 1993·Pflügers Archiv : European journal of physiology·Z Zhou, S L Lipsius
Oct 15, 1993·Brain Research·N R PrabhakarM A Haxhiu
Apr 20, 1995·Archives of Biochemistry and Biophysics·D R Arnelle, J S Stamler
Feb 1, 1995·The Journal of Clinical Investigation·M KirsteinR Fischmeister
Apr 1, 1995·Circulation Research·Y G Wang, S L Lipsius
Apr 15, 1994·The Journal of Physiology·X HanW R Giles
Jul 1, 1993·European Heart Journal·S H Rahimtoola
Jan 17, 1996·Biochemical and Biophysical Research Communications·T SekiM Naruse
May 1, 1996·Circulation Research·S I ZakharovR D Harvey
Jun 1, 1996·Circulation Research·X HanT W Smith
Apr 1, 1996·Mayo Clinic Proceedings·C WeiC G McGregor
Feb 26, 1996·FEBS Letters·C SzabóA L Salzman
Sep 1, 1996·Circulation Research·R A KellyT W Smith
Oct 1, 1996·The Journal of General Physiology·D L CampbellH C Strauss
Jul 1, 1996·Circulation Research·Y G Wang, S L Lipsius
Feb 15, 1997·The Journal of Physiology·S I Zakharov, R D Harvey
Jul 1, 1997·The Journal of Physiology·E RenströmP Rorsman
Aug 19, 1997·Circulation·Y G WangS L Lipsius
May 23, 1957·The Journal of Physiology·W H GIBSON, F J ROUGHTON
Citations
Mar 31, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·A R WhiteR J Walker
Sep 3, 2005·International Journal of Cardiology·Tsui-Min WangChern-En Chiang
Feb 28, 2001·Neuroscience Letters·C Erxleben, A Hermann
Jan 5, 2002·The Journal of General Physiology·Yong G WangStephen L Lipsius
Jul 1, 2010·Cardiovascular Research·Juan TamargoEva Delpón
Dec 18, 2003·Clinical and Experimental Pharmacology & Physiology·Lin YanHarvey R Weiss
Aug 21, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Stela M Florea, Lothar A Blatter
Jun 24, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Y G WangS L Lipsius
Sep 21, 2001·The Japanese Journal of Physiology·Y HirotaH Nakazawa
Nov 16, 2001·Journal of Molecular and Cellular Cardiology·Y WangM Ashraf
Nov 3, 2001·The Journal of Physiology·A E BelevychR D Harvey
Oct 18, 2000·The Journal of Physiology·A E Belevych, R D Harvey
Feb 17, 2001·The Journal of Physiology·N Abi-GergesP F Méry
Jul 4, 2001·The Journal of Physiology·M DittrichR Fischmeister
Apr 17, 2002·The Journal of Physiology·Najah Abi-GergesPierre-François Méry
Aug 3, 2002·The Journal of Physiology·Elena N DedkovaStephen L Lipsius
Jul 14, 2007·The Journal of Physiology·Kieran E BrackG André Ng
Jul 4, 2002·The Journal of Physiology·Glenna C L BettDonald L Campbell
Jun 11, 2005·The Journal of Physiology·Y G WangS L Lipsius
Jul 6, 2000·The Journal of Physiology·Y G WangS L Lipsius
Aug 17, 2001·The Journal of Physiology·C L Linn, A C Gafka
Apr 15, 2008·Neurochemistry International·Ceri E OldreiveGayle H Doherty
Jul 23, 2003·British Journal of Pharmacology·Robert D Harvey, Andriy E Belevych
Oct 24, 2006·British Journal of Pharmacology·M D MusamehR Motterlini
May 17, 2012·Journal of Cardiovascular Electrophysiology·Masao SakabeHiroshi Inoue
Jan 16, 2007·Cardiovascular Research·G André NgJohn H Coote
Jul 13, 2000·Critical Care Medicine·C C ChenC E Chiang
Oct 3, 1999·Circulation Research·M V Brahmajothi, D L Campbell
Nov 15, 2003·Circulation Research·Elena N DedkovaStephen L Lipsius
Nov 26, 2009·Journal of Cardiovascular Pharmacology·Muntaser D MusamehBarry J Fuller
Apr 5, 2003·American Journal of Physiology. Cell Physiology·Scott F Davis, Cindy L Linn
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Yutaro ObaraYasushi Ohizumi
May 2, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gopireddy Raghavender ReddyMoritz Bünemann
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y G WangS L Lipsius
Dec 28, 2018·International Journal of Molecular Sciences·Keisuke ImotoHideyuki Yamawaki
Jul 3, 1999·Physiological Reviews·E Carmeliet
Aug 5, 1998·The American Journal of Physiology·Y G Wang, S L Lipsius
Mar 7, 2001·Biochemical Pharmacology·J P EuG Meissner
Aug 14, 2021·Clinical Science·DongZhu XuMasaki Ieda