Nitric oxide signaling: no longer simply on or off

Trends in Biochemical Sciences
Stephen P L CaryMichael A Marletta

Abstract

Nitric oxide (NO) triggers various physiological responses in numerous tissues by binding and activating soluble guanylate cyclase (sGC) to produce the second messenger cGMP. In vivo, basal NO/cGMP signaling maintains a resting state in target cells (for example, resting tone in smooth muscle), but an acute burst of NO/cGMP signaling triggers rapid responses (such as smooth muscle relaxation). Recent studies have shown that the sGC heterodimer comprises at least four modular domains per subunit. The N-terminal heme domain is a member of the H-NOX family of domains that bind O(2) and/or NO and are conserved in prokaryotes and higher eukaryotes. Studies of these domains have uncovered the molecular basis for ligand discrimination by sGC. Other work has identified two temporally distinct states of sGC activation by NO: formation of a stable NO-heme complex results in a low-activity species, and additional NO produces a transient fully active enzyme. Nucleotides also allosterically modulate the duration and intensity of enzyme activity. Together, these studies suggest a biochemical basis for the two distinct types of NO/cGMP signal observed in vivo.

References

Oct 20, 1995·The Journal of Biological Chemistry·B WedelD Koesling
Sep 1, 1995·Progress in Cardiovascular Diseases·J M Hare, W S Colucci
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·B WedelD Koesling
Nov 5, 1997·Biochemical and Biophysical Research Communications·V G KharitonovD Koesling
Jan 31, 1998·Biochemistry·Y Zhao, M A Marletta
Jan 23, 1999·Current Opinion in Structural Biology·J J Tesmer, S R Sprang
Jan 23, 1999·Current Opinion in Structural Biology·J H Hurley
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y ZhaoM A Marletta
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·L XueJ H Szurszewski
Mar 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·T C BellamyJ Garthwaite
Apr 13, 2000·Pharmacology & Therapeutics·A M Shah, P A MacCarthy
Jun 22, 2000·Journal of Molecular Biology·L A KelleyM J Sternberg
Nov 14, 2000·The Journal of Biological Chemistry·T C Bellamy, J Garthwaite
Jan 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·D D ThomasJ R Lancaster
Mar 10, 2001·Nature·J P StaschM Schramm
Apr 11, 2001·Trends in Biochemical Sciences·M Brunori
May 9, 2001·The Journal of Clinical Investigation·S P Cary, M A Marletta
Jan 24, 2003·The Journal of Biological Chemistry·Ryu MakinoHiroshi Hori
Apr 1, 2003·The Journal of Biological Chemistry·Axel GödeckeJürgen Schrader
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura
Dec 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·I Ruiz-StewartS A Waldman
May 12, 2004·Journal of Inorganic Biochemistry·Biswajit PalTeizo Kitagawa
Jul 28, 2004·Nitric Oxide : Biology and Chemistry·M-M Cals-Grierson, A D Ormerod

❮ Previous
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Citations

Mar 19, 2013·Future Medicinal Chemistry·Pedro L Zamora, Frederick A Villamena
Feb 5, 2013·Antioxidants & Redox Signaling·Christina JankoMartin Herrmann
Jul 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nazish SayedAnnie Beuve
Aug 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Brijesh Roy, John Garthwaite
Mar 13, 2012·Annual Review of Biochemistry·Emily R Derbyshire, Michael A Marletta
Jan 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lydia W M NauschWolfgang R Dostmann
Mar 11, 2008·Journal of Bacteriology·Robert L KerbyGary P Roberts
Jan 8, 2009·Journal of Medicinal Chemistry·Haitao JiRichard B Silverman
May 2, 2009·Journal of Applied Physiology·William J PearceThomas M Lincoln
Aug 18, 2009·The Journal of Pharmacology and Experimental Therapeutics·Anbrin MasoodJames M O'Donnell
Nov 27, 2009·Antioxidants & Redox Signaling·Mayumi KajimuraMakoto Suematsu
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ying-Wu LinYi Lu
Jul 30, 2010·Inorganic Chemistry·W Robert ScheidtJ Timothy Sage
Jul 30, 2010·Inorganic Chemistry·Zachary J TonzetichStephen J Lippard
Aug 14, 2010·Inorganic Chemistry·Lindsey E McQuadeStephen J Lippard
Aug 19, 2010·Pharmacological Reviews·Sharron H FrancisDavid Sibley
Apr 16, 2011·Biochemistry·Emily R DerbyshireMichael A Marletta
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Juliano L SartorettoThomas Michel
Oct 4, 2011·Journal of the American Chemical Society·Venugopal KarunakaranPaul M Champion
Oct 27, 2011·Molecular Pharmacology·Craig UlrichIain L O Buxton
Apr 23, 2011·Journal of Nutritional Science and Vitaminology·Zhi-Qiang ChangSeung-Chun Park
Sep 29, 2011·Cellular and Molecular Life Sciences : CMLS·Manuel MorgadoIgnacio Verde
May 19, 2007·Antioxidants & Redox Signaling·Donald G Buerk
Jun 20, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Ole De BackerRomain A Lefebvre
Nov 20, 2012·Antioxidants & Redox Signaling·Antonio Martínez-RuizJuan M Serrador
Aug 24, 2007·Thyroid : Official Journal of the American Thyroid Association·Leonardo Gabriel BazzaraAna María Masini-Repiso
Mar 20, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Hongyan WangXiangshi Tan
Jun 11, 2011·New Zealand Veterinary Journal·D DamteS-C Park
Oct 23, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Aiguo ShenChun Cheng
May 24, 2012·Seminars in Nephrology·Santiago Lamas, Diego Rodríguez-Puyol
Nov 2, 2011·DNA Repair·James T MutambaBevin P Engelward
Sep 7, 2011·Plant Science : an International Journal of Experimental Plant Biology·Jéremy AstierDavid Wendehenne
Jun 2, 2010·Biochemical and Biophysical Research Communications·Biswajit Pal, Teizo Kitagawa

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