Nitric oxide synthase activity in renal cortex and medulla of normotensive and spontaneously hypertensive rats

American Journal of Hypertension
E NavaF J Salazar

Abstract

The medullary portion of the kidney plays a crucial role in the control of sodium and water excretion and arterial pressure. This control is anomalous in hypertension and may be related to an impaired renal nitric oxide (NO) production. We have measured the activity of NO synthase (NOS) in the renal medulla, renal cortex, heart, and aorta from normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Enzyme activity was determined by measuring the conversion of 14C-L-arginine to 14C-L-citrulline. Ca2+-dependent NOS activity was considerably higher in the renal medulla than in the other tissues studied, both in WKY and SHR. The medulla and heart of the SHR displayed a higher Ca2+-dependent NOS activity compared to that of WKY. No differences were found in the Ca2+-independent NOS activity, except for the renal cortex of the SHR, which was higher than in the rest of the tissues. These observations indicate that the renal medulla has a high relative capacity to synthesize NO and suggest that the impaired renal medullary control of arterial pressure of genetic hypertension is not due to a reduced NO production by the kidney.

Citations

Oct 31, 1998·Journal of Hypertension·E NavaT F Lüscher
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M G FengR L Kline
Sep 24, 2004·American Journal of Physiology. Renal Physiology·Dexter L LeeJennifer S Pollock
Dec 15, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Kyu-Tae KangJennifer S Pollock
Feb 26, 2000·Acta Physiologica Scandinavica·L G NavarJ D Imig
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carol MorenoF Javier Salazar
Mar 19, 2005·Clinical and Experimental Hypertension : CHE·Ujendra KumarAnita Sidhu
Mar 4, 1999·The Korean Journal of Internal Medicine·S W KimY J Kang
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S A DukaczR L Kline
Jan 5, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·K NakanishiY Nagai
Dec 5, 2003·Journal of Hypertension·Ana Patricia FernándezEduardo Nava
Nov 30, 1999·Journal of the American Society of Nephrology : JASN·G H AllcockD M Pollock
Sep 18, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B C Kone
Aug 12, 2008·Vascular Pharmacology·Anuran ChatterjeeJohn D Catravas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.