PMID: 7536646Feb 1, 1995Paper

Nitric oxide synthase activity is increased in patients with sepsis syndrome

Clinical Science
H F GoodeN R Webster

Abstract

1. We measured nitric oxide synthase activity in peripheral blood polymorphonuclear leucocytes from 10 patients with sepsis syndrome and 10 healthy subjects. 2. Synthase activity was significantly higher in patients with sepsis than in control subjects (1202 +/- 579 compared with 595 +/- 544 pmol of nitric oxide min-1 mg-1 of cell protein, P < 0.05). 3. Activity was greatest in those patients with the larger number of organ failures, although this failed to reach significance (1489 +/- 560 in patients with three or more organ failures and 843 +/- 404 pmol of nitric oxide min-1 mg-1 of cell protein in those with less than three, P = 0.11). 4. This study provides evidence for the role of overproduction of the vasodilator nitric oxide in sepsis syndrome.

Citations

Jun 1, 2007·Kidney International·A Cauwels
May 20, 1999·Annual Review of Pharmacology and Toxicology·A J HobbsS Moncada
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·E G SheselyO Smithies
Sep 28, 2001·British Journal of Anaesthesia·H F GalleyN R Webster
Oct 1, 1996·Critical Care Medicine·H F GalleyN R Webster
Mar 1, 1996·The Journal of Trauma·J C PreiserJ L Vincent
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·A S KristofS N Hussain
Jan 1, 1997·Lasers in Surgery and Medicine·Q ZhuT Wang
Jul 1, 1997·The British Journal of Surgery·M G Davies, P O Hagen
May 5, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephan M JakobJukka Takala
May 25, 2002·Chronobiology International·Bahar TunçtanNurettin Abacioğlu
Dec 18, 2001·Pharmacology & Therapeutics·F FeihlL Liaudet
Mar 3, 2001·Pathophysiology : the Official Journal of the International Society for Pathophysiology·K HoshiaiH Nakazawa
Dec 8, 2000·Thrombosis Research·S Sethi, M Dikshit
Jul 25, 2000·Nutrition·H K Biesalski
Nov 5, 1997·Journal of Pain and Symptom Management·M Anbar, B M Gratt

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