PMID: 8583576Mar 1, 1996Paper

Nitric oxide synthase and tyrosine hydroxylase are colocalized in nerves supplying the postnatal human male genitourinary organs

The Journal of Urology
P Y JenJ A Gosling

Abstract

The objective of this study was to examine the distribution of nitric oxide synthase (NOS) and the catecholamine-synthesizing enzyme tyrosine hydroxylase (TH) in nerve fibers supplying the human neonatal male genitourinary organs. An indirect double label immunofluorescence technique was employed on specimens obtained from infants and children at postmortem examination. Many nerve fibers immunoreactive for both NOS and TH were observed in the muscle coat of the vas deferens and the seminal vesicle, within the fibromuscular stroma of the prostate gland and at the bladder neck, and also formed perivascular plexuses in each of these organs. Double-labeled nerves occurred less frequently in the intramural ureters and superficial trigone while similar nerves in the bladder body were relatively sparse. Numerous nerves immunoreactive for NOS but not TH were observed at the base of the epithelium of each organ examined. Four types of autonomic ganglion cell were observed in nearby pelvic ganglia: those which contained NOS and TH, those which contained NOS alone, those which contained TH alone and those which contained neither NOS nor TH. The results indicate that many of the noradrenergic nerves as well as non-noradrenergic nerves supp...Continue Reading

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Citations

May 4, 2005·Pharmacology & Therapeutics·Noboru TodaTomio Okamura
Jan 10, 2002·European Journal of Pharmacology·Y MiyamotoS Ueda
Aug 23, 2002·Pharmacology & Therapeutics·S VenturaFrederick Mitchelson
Jul 22, 1998·Journal of the Autonomic Nervous System·C H HoyleP L Andrews
Dec 19, 1998·Journal of the Autonomic Nervous System·V WerkströmK E Andersson
Jun 29, 1999·British Journal of Pharmacology·P HedlundK E Andersson
Nov 17, 1998·Microscopy Research and Technique·J S DixonJ A Gosling
Apr 20, 2007·Biology of Reproduction·Travis M HagedornBruce D Schultz

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