Nitric oxide synthase-containing neurons in sensory ganglia of the rat are susceptible to capsaicin-induced cytotoxicity

Neuroscience
K Ren, M A Ruda

Abstract

Nitric oxide synthase in lumbar dorsal root ganglia of neonatal rat was studied by reduced nicotinamide adenine dinucleotide phosphate diaphorase and in situ hybridization histochemistry. Induction of nitric oxide synthase in neonatal capsaicin-treated rats after sciatic axotomy was compared with the axotomy-induced nitric oxide synthase increase observed in vehicle-treated littermates. In neonatal capsaicin-treated animals, the number of neurons constitutively labeled by reduced nicotinamide adenine dinucleotide phosphate diaphorase was greatly reduced as compared to vehicle-treated littermates. Nitric oxide synthase messenger RNA was not readily identified constitutively in dorsal root ganglion neurons. Seven days after sciatic transection the induction of reduced nicotinamide adenine dinucleotide phosphate diaphorase and nitric oxide synthase messenger RNA found in the vehicle-treated group was not observed in the capsaicin group. The presence of nitric oxide synthase in dorsal root ganglion neurons thus does not appear to protect against Ca(2+)-mediated capsaicin-induced cytotoxicity. However, since some nitric oxide synthase dorsal root ganglion neurons persist after the capsaicin neurotoxicity, nitric oxide synthase expre...Continue Reading

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·V M VergeT Hökfelt
Dec 14, 1992·Neuroscience Letters·K F KittoG L Wilcox
Dec 14, 1992·Neuroscience Letters·J G ValtschanoffH H Schmidt
Jan 1, 1992·Neuron·D S Bredt, S H Snyder
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·V L DawsonS H Snyder
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B T HopeS R Vincent
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T M DawsonS H Snyder
Apr 15, 1991·The Journal of Comparative Neurology·Y AimiH Kimura
Aug 1, 1990·Trends in Pharmacological Sciences·S Bevan, J Szolcsányi
Nov 1, 1983·Journal of Neuroscience Methods·U Scherer-SinglerE G McGeer
Feb 1, 1993·Pain·S T Meller, G F Gebhart

❮ Previous
Next ❯

Citations

Sep 18, 1999·Archives of Pharmacal Research·Y H Park, S S Lee
Sep 13, 2003·European Journal of Pharmacology·Tamás CsontPéter Ferdinandy
Feb 21, 1998·Journal of the Autonomic Nervous System·C H HoyleO Appenzeller
Nov 5, 1997·Journal of Pain and Symptom Management·M Anbar, B M Gratt
May 22, 2002·Current Opinion in Pharmacology·Roy G GoldiePaul Rigby
Mar 22, 2002·British Journal of Pharmacology·Katsushi NishiharaNaosuke Matsuura
Sep 3, 2009·Microscopy Research and Technique·Domenico RussoGiovanna Lalatta-Costerbosa
Sep 27, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Barton M Gratt, Michael Anbar
Jun 22, 2000·Anesthesiology·K OmoteA Namiki
Oct 23, 1997·The Journal of Urology·L A BirderW C de Groat
Nov 17, 1994·Annals of the New York Academy of Sciences·M A RudaK Ren
Jul 3, 2002·Molecular and Cellular Neurosciences·Michael HenrichWolfgang Kummer
Jul 15, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M Anbar, B M Gratt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.