Nitric oxide synthase-dependent vasodilation of human subcutaneous arterioles correlates with noninvasive measurements of endothelial function.

American Journal of Hypertension
Kodlipet DharmashankarMichael E Widlansky

Abstract

Noninvasive measurements of endothelial function predict future adverse cardiovascular events, but offer limited opportunities for mechanistic insights into phenotypic observations. Subcutaneous adipose arterioles, accessible through minimally invasive methods, provide an opportunity for complimentary mechanistic studies. Limited data relating subcutaneous arteriolar endothelial function, cardiovascular risk factors, and noninvasive measurements of endothelial function currently exist. Forty-four subjects underwent noninvasive studies of endothelial function (brachial reactivity (flow-mediated dilation (FMD) and digital pulse arterial tonometry (PAT)) and measurements of endothelial-dependent vasodilation of gluteal subcutaneous arterioles to acetylcholine. Arteriolar endothelial function was measured (i) percent vasodilation to maximal acetylcholine dose (10(-5) mol/l) and (ii) total area under the curve (AUC) for the entire acetylcholine dose-response curve (total AUC-acetylcholine (Ach), doses 10(-10)-10(-5) mol/l). Acetylcholine responses were almost completely nitric oxide (NO) dependent. Total AUC-Ach predicted FMD and PAT, but maximal acetylcholine vasodilation was not associated with these measures. A history of hyperte...Continue Reading

References

Oct 23, 1986·The New England Journal of Medicine·P L LudmerP Ganz
Nov 1, 1995·Journal of the American College of Cardiology·T J AndersonA C Yeung
Mar 20, 1997·The American Journal of Cardiology
Oct 13, 1998·Journal of the American College of Cardiology·D RizzoniE Agabiti-Rosei
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Atsushi SatoDavid D Gutterman
Feb 8, 2003·Circulation Research·Hiroto MiuraDavid D Gutterman
Jun 12, 2003·Journal of the American College of Cardiology·Piero O BonettiGregory W Barsness
Oct 3, 2003·Journal of the American College of Cardiology·Michael E WidlanskyJoseph A Vita
Oct 15, 2003·Circulation·Damiano RizzoniEnrico Agabiti-Rosei
Dec 8, 2004·Journal of the American College of Cardiology·Piero O BonettiAmir Lerman
Jun 28, 2005·Atherosclerosis·Stefan AgewallKarolina Kublickiene
Apr 15, 2006·Journal of Applied Physiology·Anju NohriaPeter Ganz
Oct 17, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Shane A PhillipsDavid D Gutterman
Apr 22, 2009·Cardiovascular Research·Jennifer L StrandeJohn E Baker
May 27, 2009·Trends in Cardiovascular Medicine·Naomi M Hamburg, Emelia J Benjamin
Nov 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Kyra PykeMichael Tschakovsky
Feb 27, 2010·Reviews in Endocrine & Metabolic Disorders·Corey E TabitJoseph A Vita
Jul 31, 2010·Journal of Applied Physiology·Tinoy J KizhakekuttuMichael E Widlansky
Oct 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Dick H J ThijssenDaniel J Green
Jun 7, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Beth A ParkerFrancis J Kiernan
Jul 9, 2011·Journal of Applied Physiology·Dick H J ThijssenMaria T E Hopman

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Citations

Aug 27, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Ivana GrizeljShane A Phillips
Oct 1, 2016·Vascular Medicine·Melissa G FarbNoyan Gokce
Dec 8, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Michael J TannerMichael E Widlansky
Feb 27, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Austin T RobinsonShane A Phillips
Apr 25, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Shakun KarkiNoyan Gokce
Jul 15, 2016·Journal of the American Heart Association·Daniel A FrancoRaymond Q Migrino
Feb 4, 2016·Circulation Research·David D GuttermanAndreas M Beyer
Jun 8, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Yasina B SomaniDavid N Proctor
Jan 28, 2018·EMBO Molecular Medicine·Michael E WidlanskyMingyu Liang
Nov 30, 2019·Alcoholism, Clinical and Experimental Research·Chueh-Lung HwangShane A Phillips
Mar 18, 2015·Hormone Molecular Biology and Clinical Investigation·Melissa G Farb, Noyan Gokce
Nov 5, 2013·Physiological Reports·Tisha M SubocMichael E Widlansky
Aug 23, 2019·Journal of the American Heart Association·Shakun KarkiNoyan Gokce
Oct 30, 2020·Frontiers in Medicine·Po Ying ChiaTsin Wen Yeo

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