PMID: 9662123Jul 14, 1998Paper

Nitric oxide synthase expression in bone cells

Bone
S W Fox, J W Chow

Abstract

We have localized the expression of the three main nitric oxide synthases (eNOS, bNOS, and iNOS) in bone cells of rats and humans using immunohistochemistry. The predominant isoform expressed in normal adult bone was the constitutive isoform, eNOS, mainly in cells of osteoblastic lineage. In adult bone, the osteoblast lineage cells exhibiting eNOS expression were flat bone lining cells and osteocytes, but cuboidal osteoblasts were consistently negative. Expression for bNOS was not detected in any bone cells. iNOS expression was not detected in any cells of osteoblastic lineage in normal adult rat or human bone, but was observed in cuboidal osteoblasts of adult rats with experimental colitis, in which the suppression in bone formation may be cytokine mediated. Osteoclasts in normal rat tissue showed expression for both eNOS and iNOS, but these were patchy. As for cells of the osteoblast lineage, osteoclasts were negative for bNOS. Thus, our findings support evidence, from in vitro studies and from animal experiments, that nitric oxide may play an important role in the physiology of bone.

References

May 1, 1991·Journal of Biomechanical Engineering·S C CowinM L Moss
Jan 1, 1988·Journal of Cell Science. Supplement·M Owen
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·T P KastenG A Nickols
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·C P WeinerS Moncada
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·M L BrandiI MacIntyre
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·H KoprowskiB Dietzschold
Jun 21, 1996·The Journal of Biological Chemistry·U A ArnetC J Lowenstein
Jun 1, 1996·The American Journal of Physiology·S W FoxJ W Chow

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Citations

Dec 11, 2002·The Journal of Pathology·Ester W J A AlbrechtHarry van Goor
Oct 16, 2008·Annals of Biomedical Engineering·Umut Atakan Gurkan, Ozan Akkus
Dec 29, 2010·Reviews in Endocrine & Metabolic Disorders·Erik Fink Eriksen
Dec 7, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yuming LiWeihong Yang
Mar 9, 2004·Bone·A P BergulaJ A Frangos
May 17, 2005·Bone·Yasemin BaldikGeorge A C Murrell
Sep 16, 2000·European Journal of Pharmacology·A M CortizoS B Etcheverry
Jul 17, 2001·Immunology·R J van't Hof, S H Ralston
May 6, 2008·Plastic and Reconstructive Surgery·Ines C LinRichard E Kirschner
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G ZamanL E Lanyon
Mar 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A D DiwanG A Murrell
Jun 11, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Makoto WatanukiToshitaka Nakamura
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Wei ZhuAshish D Diwan
Jan 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sze-Kwan LinChi-Yuan Hong
Oct 14, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe BanfiMassimiliano M Corsi
Sep 11, 2008·The Journal of Oral Implantology·Wihaskoro SosrosenoFikri Ibrahim
Oct 7, 2004·Sports Medicine·Crystal WhitneyKarim Khan
Jul 29, 2000·Biochemical and Biophysical Research Communications·L ManciniI MacIntyre
Aug 29, 2012·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Shinji TakahashiHiroaki Nakamura
Feb 27, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Charles J GlueckPing Wang
Mar 5, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Natalie BaeckerMartina Heer
Sep 6, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Vanessa NicolinGiorgio Zauli
May 23, 2003·Journal of Cellular Biochemistry·Jae Y JungRichard A Chole
Apr 16, 2010·Annals of the New York Academy of Sciences·Sunil J Wimalawansa
Aug 9, 2005·International Journal of Cardiology·Simon W Fox, Timothy J Chambers
Jan 14, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ana Maria Caballero-AlíasJonathan Reeve
Nov 1, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tamara A Franz-OdendaalP Eckhard Witten
May 2, 2015·Differentiation; Research in Biological Diversity·D D EhnesN I Zur Nieden
Mar 31, 2009·Journal of Dental Research·S D TanJ C Maltha
May 19, 2004·Calcified Tissue International·A M Caballero-AlíasJ Reeve
Dec 23, 2017·GeroScience·Joanna M S DaviesKelvin J A Davies
Sep 20, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jitendra PantHitesh Handa

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