Nitric oxide synthase expression in lungs of pulmonary hypertensive patients with heart disease

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
H KomaiH Kimura

Abstract

Since little is known about the contribution of endothelial nitric oxide synthase (e-NOS) to the mechanism of pulmonary vasospasm and the development of pulmonary vascular occlusive disease, we elucidate how e-NOS is expressed in lung biopsy specimens obtained from operative patients with pulmonary hypertension. Lung biopsy specimens were obtained from 17 patients who underwent open-heart operations for various heart diseases. A piece of normal lung specimen was also obtained from the resected lungs of three lung cancer patients as a control. e-NOS expression was visualized with a monoclonal antibody against e-NOS, and the level of expression was partially quantified. Significantly high levels of e-NOS expression were seen in adult patients, whose preoperative mean pulmonary arterial pressures were greater than 20 mm Hg. In contrast, e-NOS expression in pediatric patients with the same levels of mean pulmonary arterial pressure was the same as that in the controls and in low pulmonary arterial pressure. There was a statistically significant positive correlation between the level of e-NOS expression and Heath--Edwards grading. These data suggest that the e-NOS expression in lung tissue is induced when pulmonary vascular obstruct...Continue Reading

References

Jan 1, 1994·The Annals of Thoracic Surgery·H KomaiY Kawashima
May 1, 1993·The Annals of Thoracic Surgery·H KomaiY Kawashima
Jun 1, 1996·The Annals of Thoracic Surgery·D A Fullerton, R C McIntyre
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Sep 2, 1998·The Annals of Thoracic Surgery·M BeghettiI Adatia
Oct 21, 1998·Perfusion·H KomaiY Nishimura

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Citations

Oct 4, 2005·Expert Opinion on Pharmacotherapy·Werner Budts
Jun 25, 2003·Journal of the American College of Cardiology·Peter N Kao, John L Faul
Apr 27, 2002·Annals of the New York Academy of Sciences·Barry Drew, Christiaan Leeuwenburgh

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