Nitric oxide synthase gene polymorphism (G894T) influences arterial stiffness in adults: The Bogalusa Heart Study

American Journal of Hypertension
Wei ChenGerald S Berenson

Abstract

The endothelial nitric oxide synthase (eNOS) gene is known to influence the regulation of blood pressure (BP) levels. However, whether the eNOS gene locus influences arterial stiffness independently of BP is unknown. This study examines the independent effect of the eNOS gene polymorphism (G894T) on arterial stiffness in 118 African American and 285 white young adults, aged 25 to 37 years. Arterial stiffness was measured from M-mode ultrasounds of common carotid artery using Peterson's (Ep) and Young's (YEM) elastic modulus. African Americans displayed a lower frequency of the T allele than did whites (0.131 v 0.321, P <.001). The T allele was associated with lower systolic BP in African Americans (P =.04) but not in whites. African Americans showed significantly higher values of Ep (that is, increased stiffness) than did whites (49.9 kPa vs 45.5 kPa, P =.003), whereas no such difference in ethnicity was found for YEM, a measure of elasticity adjusted for relative wall thickness. After controlling for sex, age, body mass index, insulin, heart rate, and mean arterial pressure, the T allele was associated with significantly lower values of Ep (P =.037) and YEM (P =.068) in African Americans. Although the genotype effect on Ep and...Continue Reading

Associated Clinical Trials

May 26, 2000·Lydia A. Bazzano

Citations

Dec 23, 2008·Cardiovascular Research·Patrick LacolleyVeronique Regnault
Feb 24, 2007·Vascular Health and Risk Management·Alex Agrotis
Oct 1, 2007·Biomarkers in Medicine·Mahyar Khaleghi, Iftikhar J Kullo
Sep 1, 2007·Journal of the American Society of Hypertension : JASH·Azad R BhuiyanGerald S Berenson
May 24, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mohammed TiklySara Marshall
Dec 6, 2014·Nitric Oxide : Biology and Chemistry·Jitka SeidlerováMartin Pešta
Sep 29, 2017·Physiological Reviews·Patrick LacolleyStéphane Laurent
Dec 5, 2014·Journal of Cardiovascular Translational Research·Jeongok G LoganHyungsuk Kim
Jan 31, 2012·British Journal of Clinical Pharmacology·R Preston MasonTadeusz Malinski
Feb 8, 2006·The Journal of Allergy and Clinical Immunology·Kathleen C Barnes

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