Nitric oxide synthase-immunoreactive vagal afferent fibers in rat superior cervical ganglia

Neuroscience
N J DunU Förstermann

Abstract

Chronic (5-14 days) preganglionic denervation of the rat superior cervical ganglia by sectioning the cervical sympathetic trunk resulted in a time-related partial or complete loss of nitric oxide synthase (isoform I)-immunoreactive fibers and terminals surrounding many sympathetic ganglionic neurons. Unexpectedly, denervation unmasked many varicose nitric oxide synthase-immunoreactive fibers, some of which could be traced the entire length of the superior cervical ganglia. Injection of the retrograde tracer Fluorogold into the superior cervical ganglia labeled a population of nodose ganglion cells and of dorsal root ganglion cells from C8 to T3 segments. When the same sections were processed for nitric oxide synthase-immunoreactivity, 40% of the Fluorogold-containing nodose ganglion cells also expressed nitric oxide synthase-immunoreactivity, whereas colocalization was observed in only a few dorsal root ganglion cells. Similarly, injection of Fluorogold into denervated superior cervical ganglia labeled a population of nodose ganglion cells. Sectioning of all nerve trunks associated with the superior cervical ganglion prior to injection of Fluorogold, except the cervical sympathetic trunk, resulted in no detectable labeling of F...Continue Reading

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Citations

Jun 1, 1997·Progress in Neurobiology·H ZhuoC J Helke
Jun 26, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E HösliL Hösli
Apr 29, 2006·Journal of Applied Physiology·Conwin K VanterpoolJohn N Buchholz
Nov 26, 2009·Journal of Neuroscience Research·Hui-ya HsiehAgnieszka Balkowiec
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Nov 16, 2002·Journal of Applied Physiology·Emmanuel M MbakuJohn Buchholz

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