Nitric oxide synthase in models of focal ischemia

Stroke; a Journal of Cerebral Circulation
A F SamdaniV L Dawson

Abstract

Cessation of blood flow to the brain, for even a few minutes, sets in motion a potential reversible cascade of events resulting in neuronal cell death. Oxygen free radicals and oxidants appear to play an important role in central nervous system injury after cerebral ischemia and reperfusion. Recently, divergent roles for the newly identified neuronal messenger molecule and oxygen radical, nitric oxide (NO), have been identified in various models of cerebral ischemia. Because of the chemical and physical properties of NO, the numerous physiological activities it mediates, and the lack of specific agents to modulate the activity of the different isoforms of NO synthase (NOS), reports regarding the role of NO in focal cerebral ischemia have been confounding and often conflicting. Recent advances in pharmacology and the development of transgenic knockout mice specific for the different isoforms of NOS have advanced our knowledge and clarified the role of NO in cerebral ischemia. Animal models of focal ischemia employ occlusion of nutrient cerebral vessels, most commonly the middle cerebral artery. Primary cortical cultures are exposed to excitotoxic or ischemic conditions, and the activities of NOS isoforms or NO production are eva...Continue Reading

References

Sep 1, 1992·Annals of Neurology·T M DawsonS H Snyder
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B T HopeS R Vincent
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T M DawsonS H Snyder
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H KinouchiP H Chan
Sep 1, 1990·Trends in Pharmacological Sciences·B Meldrum, J Garthwaite
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L DinermanS H Snyder
Sep 23, 1994·Cell·C Nathan, Q W Xie
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T YoshidaM A Moskowitz
Jan 1, 1994·Annual Review of Biochemistry·D S Bredt, S H Snyder
May 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C IadecolaM E Ross
Jan 1, 1995·Annual Review of Physiology·J Garthwaite, C L Boulton
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Q WangR F Albrecht
Jan 1, 1994·Progress in Brain Research·D W Choi
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·W L GrossR A Kelly
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y XiaJ L Zweier
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Z HuangM A Moskowitz
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·L A MacMillan-CrowJ A Thompson
Nov 1, 1996·The American Journal of Physiology·J S Beckman, W H Koppenol
Jul 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Z G ZhangM Chopp
Jul 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H HaraM A Moskowitz
Jan 1, 1996·Critical Reviews in Neurobiology·H Y YunT M Dawson
Mar 1, 1997·Trends in Neurosciences·C Iadecola

❮ Previous
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Citations

Feb 24, 2000·The Journal of Pathology·H Li, U Förstermann
Sep 30, 1998·Journal of Neuroscience Research·F W HoltsbergS M Steiner
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·O P MishraM Delivoria-Papadopoulos
Aug 27, 2003·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·G YangD Wang
Sep 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D J ColeW K Jacobsen
May 29, 2004·Journal of Physiology and Biochemistry·A GámezR Rama
May 18, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Meng QiJixin Shi
Jun 6, 2009·Journal of Inherited Metabolic Disease·J M Politei
May 20, 2006·Cellular and Molecular Neurobiology·Konstantin-Alexander Hossmann
Sep 12, 2008·Cellular and Molecular Neurobiology·Qin LiLian-Jun Guo
Jul 14, 2010·Cellular and Molecular Neurobiology·Hiroto UchidaTsutomu Araki
Aug 8, 2008·Journal of Molecular Histology·Dimka Hinova-PalovaWladimir Ovtscharoff
Jun 9, 2009·Current Atherosclerosis Reports·Larry B Goldstein
Jun 16, 2009·Neurotoxicity Research·Gjumrakch AlievValentin Bragin
Jan 20, 2004·European Journal of Pharmacology·Yangzheng FengMichael H LeBlanc
Jun 7, 2005·Experimental Neurology·Dominique LerouetIsabelle Margaill
Mar 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Santhanam A V Raghavan, Madhu Dikshit
Aug 21, 2001·Brain Research·P ManningP J Shaw
Nov 8, 2001·European Journal of Pharmacology·G FolkertsF P Nijkamp
Oct 31, 2000·Journal of the Neurological Sciences·B C WhiteG S Krause
Oct 22, 2003·Journal of the Neurological Sciences·Satoshi ShibutaTakashi Mashimo
Apr 15, 1999·Journal of the Neurological Sciences·R R LekerH Ovadia
Aug 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Babu V NaiduMichael S Mulligan
Oct 8, 2003·Neuropharmacology·Lorraine V Kalia, Michael W Salter
Jun 28, 2002·Brain Research. Brain Research Reviews·Ronen R Leker, Esther Shohami
Jun 7, 2003·Brain Research. Brain Research Reviews·R R Leker, M Y Neufeld
Dec 5, 1998·Brain Research. Developmental Brain Research·M SantacanaJ Rodrigo

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