PMID: 7541208Mar 1, 1995Paper

Nitric oxide synthase in the hypothalamo-pituitary pathways

Journal of Chemical Neuroanatomy
S Vanhatalo, S Soinila

Abstract

Several histochemical and physiological studies in the literature suggest that nitric oxide (NO) is involved in the posterior pituitary regulation. This study was set out to demonstrate the distribution of the pituitary projecting nitric oxide containing hypothalamic pathways. The fluorescent retrograde tracer fluorogold (FG) was injected into the pituitary gland in order to reveal the hypothalamic nuclei projecting to the pituitary gland. Nitric oxide synthase (NOS) was subsequently visualized from the same sections by NADPH-diaphorase histochemistry. More than 70% of the FG labelled neurons in the preoptic area, paraventricular, supraoptic, retrochiasmatic, anterior commissural and circular nuclei as well as in many other small neurosecretory centers in the hypothalamus contained also NADPH-diaphorase activity (NADPH-DA). In addition, some of the neurons in the periventricular nucleus as well as occasional neurons in the lateral hypothalamus projecting to the pituitary gland contained NADPH-DA. The present results give the first systematic neuroanatomical description of the hypothalamic NO synthase containing neurons projecting into the pituitary gland. They indicate that the pituitary receives a widely distributed NO innerva...Continue Reading

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Citations

Jul 17, 1999·Brain Research. Brain Research Reviews·T L Krukoff
Jan 9, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E SzabatS Soinila
Mar 14, 1998·Journal of Chemical Neuroanatomy·W AllaertsE W Roubos
Dec 4, 2002·Acta Neurologica Scandinavica·A KruseM Lauritzen
Jan 24, 2009·Physiology & Behavior·Oscar González-FloresAnne M Etgen
Feb 1, 2011·The Journal of Comparative Neurology·Danielle A Simmons, Pauline Yahr
Dec 2, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T González-Hernández, M C González
Jan 26, 2002·Microscopy Research and Technique·Takashi Higuchi, Chuma O Okere
Oct 1, 2004·The Journal of Comparative Neurology·Mariarosa G SpinaMario Engelmann
Oct 25, 2016·Physiological Research·A Puzserova, I Bernatova
Mar 27, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D N WatkinsP J Thompson
Jan 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Stephanie ConstantinSusan Wray

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