Nitric oxide synthase inhibition and food intake: effects on motivation to eat and in female mice

Pharmacology, Biochemistry, and Behavior
J E MorleyJ F Flood

Abstract

Recent studies have demonstrated that nitric oxide may play an important role in the regulation of food intake. The studies reported here extend these findings by demonstrating that NG-nitro-arginine-methylester, N-Arg(ME), a nitric oxide synthase inhibitor, decreased intake of a highly palatable substance (i.e., milk), though at a higher dose than necessary for decreasing consumption of food pellets. N-Arg(ME) failed to inhibit lever press for milk reward in nonprefed mice, but decreased lever pressing in prefed mice. N-Arg(ME) decreased food intake in female mice, being most potent in proestrus. These studies suggest that nitric oxide synthase inhibition decreases food intake without inducing aversion or illness.

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Citations

Sep 5, 1996·European Journal of Pharmacology·J E MorleyJ F Flood
Nov 1, 1996·Pharmacology, Biochemistry, and Behavior·D A Czech
May 1, 1997·Pharmacology, Biochemistry, and Behavior·M A PrendergastA V Terry
Nov 5, 1997·Pharmacology, Biochemistry, and Behavior·F Lallemand, P De Witte
Jun 4, 1998·Pharmacology, Biochemistry, and Behavior·D A CzechK T Le Sueur
Sep 2, 2003·Peptides·F Spencer GaskinJohn E Morley
Jan 1, 1997·Brain Research Bulletin·S Ceccatelli
Jul 29, 2003·Genes, Brain, and Behavior·G E Robinson, Y Ben-Shahar
Oct 6, 2009·Physiology & Behavior·Carmen Agustín-PavónEnrique Lanuza
May 7, 2008·Journal of the American Medical Directors Association·Shing-Shing YehMichael W Schuster
Apr 6, 2005·Peptides·Susan A FarrJohn E Morley
May 14, 2011·Journal of Clinical Laboratory Analysis·Hikmet KocakDeniz Esin
Aug 30, 2008·Nutrition·John E Morley, Susan A Farr
Mar 1, 2003·Clinics in Geriatric Medicine·John E Morley
Aug 19, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eva SzentirmaiJames M Krueger
Dec 31, 2020·International Journal of Molecular Sciences·Patrick O'BrienChristopher P Corpe
Nov 14, 1997·Frontiers in Neuroendocrinology·R J NelsonT M Dawson
Apr 27, 2002·Science·Y Ben-ShaharG E Robinson

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