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Nitric oxide synthase inhibition depresses the height of the cerebral blood flow-pressure autoregulation curve during moderate hypotension

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism

Sep 1, 2003

Stephen C JonesAlejandro D Perez-Trepichio

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Abstract

Variations in the height of the CBF response to hypotension have been described recently in normal animals. The authors evaluated the effects of nitric oxide synthase (NOS) inhibition on these variations in height using laser Doppler flowmetry in 42 anesthetized (halothane and N2O) male...read more

Mentioned in this Paper

Alloenzymes
Rats, Holtzman
Hypotension
Velocimetry, Laser-Doppler
Regional Blood Flow
Nitroarginine
Cerebrovascular Circulation
Enzyme Inhibitors
Diastolic Blood Pressure
Nitric Oxide Synthase
Paper Details
References
  • References21
  • Citations7
123

Nitric oxide synthase inhibition depresses the height of the cerebral blood flow-pressure autoregulation curve during moderate hypotension

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism

Sep 1, 2003

Stephen C JonesAlejandro D Perez-Trepichio

PMID: 12973025

DOI: 10.1097/01.wcb.0000081202.00668.fb

Abstract

Variations in the height of the CBF response to hypotension have been described recently in normal animals. The authors evaluated the effects of nitric oxide synthase (NOS) inhibition on these variations in height using laser Doppler flowmetry in 42 anesthetized (halothane and N2O) male...read more

Mentioned in this Paper

Alloenzymes
Rats, Holtzman
Hypotension
Velocimetry, Laser-Doppler
Regional Blood Flow

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Paper Details
References
  • References21
  • Citations7
123

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