PMID: 9171957Jun 1, 1997Paper

Nitric oxide synthase inhibition in a spontaneously hypertensive rat model of diabetic nephropathy

Clinical and Experimental Pharmacology & Physiology
J WesselsG J Macdonald

Abstract

1. To investigate the role of nitric oxide (NO) in diabetic nephropathy the effect of nitric oxide synthase (NOS) inhibition by NG-nitro-L-arginine methyl ester (L-NAME) was observed in a streptozotocin diabetic spontaneously hypertensive rat (SHR) model. 2. Two groups of SHR (n = 8) with streptozotocin-induced diabetes were studied. One group was given L-NAME 5 mg/kg bodyweight per day in the drinking water for 8 weeks while both groups received daily subcutaneous injections of Ultratard insulin. Creatinine clearance, urinary protein excretion, urinary nitrate concentration and systolic blood pressure were measured at fortnightly intervals. Rats were killed at 8 weeks and plasma angiotensin II (AngII) was measured by radioimmunoassay. 3. Renal function (endogenous creatinine clearance) remained stable in both groups. In the L-NAME group, however, there was a progressive increase in proteinuria that was highly significant at 6 weeks (22.1 +/- 2.9 compared with 6.5 +/- 0.7 mg/ 24 h per 100 g in control SHR diabetic rats P < 0.001). 4. Systolic blood pressure was significantly elevated in the L-NAME group throughout the study compared with the control group. 5. Plasma AngII was significantly elevated in the L-NAME group compared ...Continue Reading

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Citations

May 2, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pervin VuralMukaddes Canbaz
Jul 1, 1998·Clinical Biochemistry·G EllisS K Makela
Aug 9, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Dilek YavuzSema Akalin
Jul 15, 2004·Seminars in Nephrology·Sharma S Prabhakar
Mar 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Yu-Jung ChenJohn Quilley
Nov 1, 2002·Journal of Cardiovascular Pharmacology·Christiane Martina ErleyHartmut Osswald
Nov 21, 2009·Journal of Clinical Laboratory Analysis·Ivanka MikulićMonika Zeljko-Tomić
Dec 14, 1999·Journal of Endocrinological Investigation·G PuglieseU Di Mario
Jun 16, 2001·American Journal of Physiology. Renal Physiology·S S Prabhakar
Jun 7, 2006·European Journal of Pharmacology·Yu-Jung ChenJohn Quilley

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