PMID: 9170340May 1, 1997Paper

Nitric oxide synthase inhibition in the histamine headache model

Cephalalgia : an International Journal of Headache
L SchmettererE A Singer

Abstract

Histamine has been widely used experimentally to induce headache in healthy subjects and migraine in migraineurs. There is evidence that the vascular effects of histamine are at least partially mediated by nitric oxide (NO). Hence we hypothesized that subjective symptoms and hemodynamic effects of histamine could be reduced by systemic NO-synthase inhibition. We therefore studied the effect of pretreatment with N-monomethyl-L-arginine (L-NMMA), a competitive inhibitor of NO-synthase, or placebo on headache, flush and discomfort scores during histamine infusion. Additionally, blood flow velocities in the middle cerebral and the ophthalmic artery and ocular fundus pulsations were measured. Whereas L-NMMA blunted the effect of histamine in the ophthalmic artery and the ocular circulation, NO-synthase inhibition did not mitigate subjective symptoms. Histamine did not affect mean blood flow velocities in the middle cerebral artery. Hence, we conclude that NO-synthase inhibition reduces the histamine-induced vascular effects in the ocular circulation, but is not sufficient to attenuate or abort the subjective symptoms provoked by histamine infusion.

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Citations

Aug 5, 1998·International Journal of Clinical & Laboratory Research·P MartellettiM Giacovazzo
Nov 12, 2002·Brain Research·Simon AkermanPeter J Goadsby
Mar 27, 1998·Life Sciences·J Koller-StrametzL Schmetterer
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Nov 30, 2018·Nutritional Neuroscience·Samaneh HajjarzadehZeinab Nikniaz
May 30, 2008·Acta Ophthalmologica·Hemma ReschLeopold Schmetterer
Aug 19, 2015·Headache·Elena García-MartínFélix Javier Jiménez-Jiménez
Jun 3, 2011·Headache·Saurabh GuptaB Lee Peterlin
Mar 27, 2019·The Journal of Headache and Pain·Jacob WormJes Olesen
May 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Guido T DornerLeopold Schmetterer
Jul 9, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hemma ReschGerhard Garhöfer
Oct 5, 2016·Headache·Vincent T Martin, Brinder Vij
Jun 11, 1999·The American Journal of Physiology·B KissL Schmetterer
Jun 10, 2021·Headache·Maria Dolores Villar-MartínezPeter J Goadsby

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