PMID: 8968184Dec 1, 1996Paper

Nitric oxide synthase inhibition modulates the ventilatory depressant and antinociceptive actions of fourth ventricular infusions of morphine in the awake dog

Anesthesiology
D A PelligrinoT R VadeBoncouer

Abstract

The role of nitric oxide (NO) production, at the brain-stem level, in ventilatory control and pain perception is poorly understood. Furthermore, it is not clear whether NO synthase (NOS) inhibition can affect morphine-induced ventilatory depression or analgesia. The central hypothesis of this investigation was that NO, at supraspinal sites, can influence ventilation and nociception and can modulate the ventilatory depressant and antinociceptive actions of morphine. Using drug delivery via the fourth cerebral ventricle, the authors examined the ventilatory and nociceptive effects of an NOS inhibitor and an NO donor in the presence or absence of morphine sulfate (MS). The studies were performed in awake dogs that were restrained in a stanchion using a fourth ventricle to cisterna magna perfusion system. The dogs were chronically prepared with fourth ventricle and cisterna magna guide cannulae, femoral arterial/venous catheters, and a tracheostomy. Agents were prepared in a temperature- and pH-controlled artificial cerebrospinal fluid, perfused at 1 ml/min through the fourth ventricle cannula, and permitted to flow out through the cisterna magna cannula. The authors measured PaCO2, ventilatory drive (inspiratory occlusion pressure...Continue Reading

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Citations

Nov 19, 2009·Journal of Anesthesia·Noboru TodaHiroshi Toda
Oct 19, 2000·Journal of Chemical Neuroanatomy·R Pego-ReigosaP Pesini
Feb 3, 1999·Lancet·N Benjamin
Aug 9, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Dimitris E EmmanouilRaymond M Quock
Jul 5, 2011·Nitric Oxide : Biology and Chemistry·Yara CurySergio Henrique Ferreira
Dec 9, 2014·Behavioural Pharmacology·Magdalena Bujalska-ZadrożnyŁukasz Nagraba
Dec 24, 2008·Anesthesiology·Noboru TodaHiroshi Toda
Aug 11, 2016·Behavioural Pharmacology·Magdalena Bujalska-ZadrożnyMariusz Sacharczuk
Apr 6, 2000·Journal of Applied Physiology·D D KlineN R Prabhakar

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