PMID: 8938822Oct 1, 1996Paper

Nitric oxide synthase inhibitor L-NAME prevents amphetamine-induced prodynorphin gene expression in the rat

Progress in Neuro-psychopharmacology & Biological Psychiatry
B PrzewłockaW Lasoń

Abstract

1. The effect of nitric oxide synthase inhibitor on amphetamine-induced behavioral changes and prodynorphin gene expression in the nucleus accumbens and striatum of the rat has been studied. 2. L-NAME attenuated behavioral stereotypic activity evoked by amphetamine administration. 3. Acute amphetamine administration (5mg/kg i.p.) increased the prodynorphin mRNA level in the nucleus accumbens and striatum after 3 hr. 4. A nitric oxide synthase inhibitor L-nitro-arginine methyl ester (L-NAME, 10, 50 mg/kg i.p.) had no effect on the level of prodynorphin mRNA, but prevented dose-dependently the amphetamine-induced increase in prodynorphin gene expression in both the nucleus accumbens and the striatum. 5. These data indicate that inhibition of the nitric oxide pathway attenuates biochemical and behavioral effects of amphetamine.

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Citations

Dec 9, 2003·European Journal of Pharmacology·Mohammad-Reza ZarrindastAli Haeri-Rohani
Feb 13, 2001·Neuroscience and Biobehavioral Reviews·I Tayfun Uzbay, M W Oglesby
Feb 17, 1998·Neuroscience Letters·B PrzewłockaR Przewłocki
Mar 29, 2001·Brain Research Bulletin·R E HarlanM M Garcia
Sep 11, 1999·Drug and Alcohol Dependence·T CelikI T Uzbay
Aug 13, 2021·Neural Regeneration Research·Jakša VukojevicPredrag Sikirić

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