Nitric oxide synthase inhibitors cause motor deficits in mice

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
T ArakiY Itoyama

Abstract

We investigated possible motor effects of 7-nitroindazole (7-NI), an neuronal nitric oxide synthase (nNOS) inhibitor, and N(G)-nitro-L-arginine methyl ester (L-NAME), an non-selective NOS inhibitor in mice using catalepsy and pole tests in comparison with dopamine D(2) receptor antagonist, haloperidol. We also studied the change in dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) contents of these compounds. The administration of 7-NI and L-NAME (40-160 mg/kg, s.c.) dose-dependently induced motor deficit in both catalepsy and pole tests. The motor deficit induced by 7-NI was more pronounced than the one produced by L-NAME. In contrast, haloperidol showed a marked motor deficit in mice. Haloperidol showed a marked motor deficit as compared with 7-NI and L-NAME. For dopamine, DOPAC and HVA contents, haloperidol exhibited a significant decrease in dopamine content and a significant increase in DOPAC and HVA content in the striatum. In contrast, 7-NI showed a significant increase in the striatal dopamine content. However, 7-NI had no significant change in the striatal DOPAC and HVA contents. On the other hand, no significant change in the striatal dopamine, DOPAC and HVA contents was observed in L-NAME-t...Continue Reading

References

Jan 1, 1978·European Journal of Pharmacology·K B KofferO Hornykiewicz
Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S YamamotoD J Reis
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·V L DawsonS H Snyder
Nov 12, 1991·European Journal of Pharmacology·J P NowickiB Scatton
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·L J Ignarro
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C IadecolaN A Lassen
Jul 1, 1993·Journal of Neurochemistry·O Manzoni, J Bockaert
Jan 1, 1995·Brain Research Bulletin·N T SandorB Lendvai
Jan 16, 1995·European Journal of Pharmacology·M S Starr, B S Starr
Oct 1, 1994·The European Journal of Neuroscience·C L BoultonG L Collingridge
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D W Choi
Dec 29, 1995·Neuroreport·R A MarrasF S Guimarães
May 15, 1998·General Pharmacology·E A Del BelF S Guimarães

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Citations

Jul 29, 2005·Cellular and Molecular Neurobiology·E A Del BelD de Paula-Souza
Feb 6, 2004·European Journal of Pharmacology·Elaine A Del BelMarcela Bermúdez-Echeverry
Mar 23, 2004·Behavioural Brain Research·Carmen ManzanedoJosé Miñarro
Dec 25, 2002·Neurobiology of Aging·Rumiko KurosakiTsutomu Araki
Mar 11, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Haseeb Ahmad Khan
Mar 21, 2006·European Journal of Pharmacology·Meigy T TadaieskyMaria A B F Vital
Feb 21, 2008·Nutritional Neuroscience·Lane Coelho VianaCristovam Wanderley Picanço Diniz
Jul 16, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Heike KielsteinJan T Kielstein
Oct 6, 2009·Journal of Neurochemistry·Diana J Park, Anthony R West
Jul 9, 2011·Neurochemistry International·Ozlem OzsoyMutay Aslan
May 26, 2004·Nitric Oxide : Biology and Chemistry·Rachel WeitzdoerferBarbara Lubec
Mar 2, 2006·European Journal of Anaesthesiology·U ErkentM Ilhan
Apr 6, 2021·The European Journal of Neuroscience·Isabelle WakuAmanda R de Oliveira
May 26, 2004·Pharmacology, Biochemistry, and Behavior·Rumiko KurosakiTsutomu Araki

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