Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test

doi:10.1016/s0014-2999(99)00191-0

PMID: 10395013DOI: 10.1016/s0014-2999(99)00191-0Jul 8, 1999Paper

Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test

European Journal of Pharmacology

A HarkinIan A Paul

Abstract

Previous studies have demonstrated that antagonists at the NMDA receptor are as efficacious as tricyclic antidepressants in pre-clinical antidepressant screening procedures and in blocking or reversing the behavioral deficits associated with animal analogs of major depressive symptomatology. The NMDA receptor complex gates Ca2+, which interacts with calmodulin to subsequently activate nitric oxide (NO) synthase. We hypothesized that NO synthase antagonists might display antidepressant-like properties, similar to NMDA receptor antagonists. We examined the effects of N(G)-nitro-L-arginine (L-NNA), its dextrorotatory enantiomer, D-NNA, N(G)-nitro-L-arginine methyl ester (L-NAME) and N(G)-monomethyl-L-arginine (L-NMMA) at doses from 1 to 30 mg/kg in the forced swim test in mice. We now report that NO synthase antagonists are as efficacious as imipramine (15 mg/kg) in reducing the duration of immobility in the mouse forced swim test. The effects of NO synthase antagonists, as well as those of imipramine were blocked by pre-treatment with L-arginine (L-Arg) (500 mg/kg). In contrast to imipramine, the NO synthase antagonists were without effect on locomotor activity over the dose range active in the forced swim test (3-10 mg/kg). Like...Continue Reading

References

Down-regulation of cortical beta-adrenoceptors by chronic treatment with functional NMDA antagonists

Jan 1, 1992·Psychopharmacology·I A PaulG Nowak

Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

May 7, 1992·Nature·H MeguroM Mishina

Increase of nitric oxide production by L-arginine potentiates i.c.v. administered beta-endorphin-induced antinociception in the mouse

Mar 3, 1992·European Journal of Pharmacology·L F TsengG M Pieper

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

Jun 1, 1992·Neuron·S Z LeiS A Lipton

Modulation of the behavioural effects of interleukin-1 in mice by nitric oxide

Feb 1, 1992·Neuroreport·R M BluthéR Dantzer

NG-nitro-L-arginine enhances neuronal death following transient forebrain ischemia in gerbils

Nov 9, 1992·Neuroscience Letters·B A WeissmanS Shapira

Inhibition of long-term potentiation by NMDA-mediated nitric oxide release

Aug 28, 1992·Science·Y IzumiC F Zorumski

Chronic treatment with 1-aminocyclopropanecarboxylic acid desensitizes behavioral responses to compounds acting at the N-methyl-D-aspartate receptor complex

Jan 1, 1992·Psychopharmacology·P SkolnickR Trullas

Effects of MK-801 and antidepressant drugs in the forced swimming test in rats

Mar 1, 1992·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J MajH Sowińska

1-aminocyclopropanecarboxylates exhibit antidepressant and anxiolytic actions in animal models

Oct 22, 1991·European Journal of Pharmacology·R TrullasP Skolnick

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada

Nitric oxide synthesis in the CNS endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues

Jan 1, 1991·Life Sciences·L E LambertI A McDonald

Functional antagonists at the NMDA receptor complex exhibit antidepressant actions

Aug 21, 1990·European Journal of Pharmacology·R Trullas, P Skolnick

Pharmacological characteristics of cyclic homologues of glycine at the N-methyl-D-aspartate receptor-associated glycine site

Aug 1, 1990·Neuropharmacology·G B Watson, T H Lanthorn

1-Aminocyclopropane carboxylic acid: a potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate receptor complex.

Mar 1, 1989·Journal of Neurochemistry·J C MarvizónP Skolnick

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase

Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G KnowlesS Moncada

Further evidence that noradrenaline is not involved in the anti-immobility activity of chronic desipramine in the rat

Apr 29, 1987·European Journal of Pharmacology·E EspositoR Samanin

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

Jun 30, 1988·Biochemical and Biophysical Research Communications·R M PalmerS Moncada

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist

Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E H WongL L Iversen

The effect of imipramine on central monoamine neurons

Mar 1, 1968·The Journal of Pharmacy and Pharmacology·H Corrodi, K Fuxe

Presynaptic alpha-adrenoceptors and the action of tricyclic antidepressant drugs in behavioural despair in rats

Jan 1, 1980·Psychopharmacology·I Zebrowska-Lupina

Immobility test: effects of 5-hydroxytryptaminergic drugs and role of catecholamines in the activity of some antidepressants

Jan 1, 1981·The Journal of Pharmacy and Pharmacology·F BorsiniR Samanin

The nitric oxide-cyclic GMP signalling pathway in rat brain

Nov 1, 1993·Neuropharmacology·E Southam, J Garthwaite

Neuroprotective efficacy of N omega-nitro-L-arginine after focal cerebral ischemia in the mouse and inhibition of cortical nitric oxide synthase

May 2, 1994·European Journal of Pharmacology·A CarreauJ P Nowicki

Nitro-L-arginine analogues. Dose- and time-related nitric oxide synthase inhibition in brain

May 1, 1995·Stroke; a Journal of Cerebral Circulation·R J TraystmanP D Hurn

Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats

Feb 14, 1995·European Journal of Pharmacology·C RundfeldtW Löscher

Nitric oxide synthase activity endogenously modulates NMDA receptors

Jul 1, 1993·Journal of Neurochemistry·O Manzoni, J Bockaert

Dizocilpine antagonizes the effect of chronic imipramine on learned helplessness in rats

Oct 1, 1993·Pharmacology, Biochemistry, and Behavior·D MeloniA Tagliamonte

L-arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway

May 1, 1993·British Journal of Pharmacology·A KawabataH Takagi

Effects of L-NOARG on plus-maze performance in rats

Jan 1, 1997·Pharmacology, Biochemistry, and Behavior·C L De OliveiraF S Guimarães

A molecular and cellular theory of depression

Jul 1, 1997·Archives of General Psychiatry·R S DumanE J Nestler

Behavioural and neurochemical effects of dizocilpine in the olfactory bulbectomized rat model of depression

Sep 23, 1997·Pharmacology, Biochemistry, and Behavior·A M RedmondB E Leonard

INHIBITION OF UPTAKE OF TRITIATED-NORADRENALINE IN THE INTACT RAT BRAIN BY IMIPRAMINE AND STRUCTURALLY RELATED COMPOUNDS

Dec 26, 1964·Nature·J GLOWINSKI, J AXELROD

❮ Previous

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Citations

Opposite effects of milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of nitric oxide and brain-derived neurotrophic factor in mouse brain cortex.

Nov 7, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Atsuko Ikenouchi-SugitaNobuyuki Yanagihara

Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice

Aug 4, 2004·Psychopharmacology·H MiuraN Ozaki

Forced swimming test in mice: a review of antidepressant activity

Dec 21, 2004·Psychopharmacology·Benoit Petit-DemouliereMichel Bourin

Inhibition of neuronal nitric oxide synthase in the rat hippocampus induces antidepressant-like effects

Mar 7, 2006·Psychopharmacology·Sâmia Regiane Lourenço Joca, Francisco Silveira Guimarães

DETA/NONOate, a nitric oxide donor, produces antidepressant effects by promoting hippocampal neurogenesis.

May 31, 2008·Psychopharmacology·Yao HuaDong-Ya Zhu

NMDA receptor/nitrergic system blockage augments antidepressant-like effects of paroxetine in the mouse forced swimming test.

Jul 18, 2009·Psychopharmacology·Mehdi GhasemiAhmad Reza Dehpour

Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies

Sep 8, 2007·Journal of Neural Transmission·C B BrinkB H Harvey

Influence of pegylated interferon-alpha therapy on plasma levels of citrulline and arginine in melanoma patients

Apr 20, 2006·Amino Acids·D FekkesG Stoter

The involvement of NMDA and AMPA receptors in the mechanism of antidepressant-like action of zinc in the forced swim test

Dec 4, 2009·Amino Acids·B SzewczykGabriel Nowak

The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice

May 14, 2005·Neuroscience and Biobehavioral Reviews·John F CryanAnnick Vassout

Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin in the mouse hippocampus

Feb 21, 2004·Neuropharmacology·H MiuraT Ohta

Dual effects of nitric oxide in the mouse forced swimming test: possible contribution of nitric oxide-mediated serotonin release and potassium channel modulation

Mar 10, 2004·Pharmacology, Biochemistry, and Behavior·Salim Yalcin InanFazilet Aksu

Antidepressants: past, present and future

Oct 18, 2000·European Journal of Pharmacology·J Vetulani, I Nalepa

Group housing of mice increases immobility and antidepressant sensitivity in the forced swim and tail suspension tests

Mar 29, 2001·European Journal of Pharmacology·B Karolewicz, I A Paul

Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice

Aug 9, 2002·European Journal of Pharmacology·Hiroshi TakedaTeruhiko Matsumiya

The Vogel conflict test: procedural aspects, gamma-aminobutyric acid, glutamate and monoamines

Feb 26, 2003·European Journal of Pharmacology·Mark J Millan, Mauricette Brocco

Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 2. Chronic treatment results in downregulation of cortical beta-adrenoceptors

Jul 8, 1999·European Journal of Pharmacology·B KarolewiczI A Paul

NMDA receptor involvement in imipramine withdrawal-associated effects on swim stress, GABA levels and NMDA receptor binding in rat hippocampus

May 22, 2002·Life Sciences·Brian H HarveyDan J Stein

Antidepressant-like actions of an AMPA receptor potentiator (LY392098)

Jun 19, 2001·Neuropharmacology·X LiP Skolnick

Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors

Apr 2, 2003·Neuropharmacology·A HarkinJ P Kelly

Intra- and interstrain differences in models of "behavioral despair"

Nov 10, 2001·Pharmacology, Biochemistry, and Behavior·F BaiP Skolnick

Delayed stress-induced antinociceptive effect of nitric oxide synthase inhibition in the dentate gyrus of rats

Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Marcela B EcheverryElaine A Del Bel

Effects of excitatory amino acids and nitric oxide on flight behavior elicited from the dorsolateral periaqueductal gray

Jan 22, 2002·Neuroscience and Biobehavioral Reviews·R M De OliveiraF S Guimarães

Elevated plasma nitrate levels in depressive states

Mar 14, 2001·Journal of Affective Disorders·E SuzukiM Asai

Nitric oxide modulates lithium-induced conditioned taste aversion

Feb 13, 2001·Behavioural Brain Research·G WegenerR Rosenberg

Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats

Aug 23, 2002·Behavioural Brain Research·Ida Louise HeibergRaben Rosenberg

Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice

Mar 20, 2003·Behavioural Brain Research·Vallo VolkeEero Vasar

Involvement of NMDA receptors and L-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice

Aug 30, 2003·Behavioural Brain Research·Angelo Oscar RosaAna Lúcia S Rodrigues

Effects of nitric oxide synthase inhibitors 7-NI, L-NAME, and L-NOARG in staircase test

May 29, 2002·Archives of Medical Research·Paavo Pokk, Marika Väli

The effects of the nitric oxide synthase inhibitors on the behaviour of small-platform-stressed mice in the plus-maze test

Jan 31, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Paavo Pokk, Marika Väli

The neurobiology and control of anxious states

Aug 21, 2003·Progress in Neurobiology·Mark J Millan

Antipsychotic, antidepressant, anxiolytic, and anticonvulsant drugs induce type II nitric oxide synthase mRNA in rat brain

Nov 14, 2002·Neuroscience Letters·Eiji SuzukiHitoshi Miyaoka

Unaltered radial maze performance and brain acetylcholine of the endothelial nitric oxide synthase knockout mouse

Nov 27, 2001·Neuroscience·E DereJ P Huston

Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice

Mar 1, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marika V DoucetAndrew Harkin

Endogenous nitric oxide decreases hippocampal levels of serotonin and dopamine in vivo

May 24, 2000·British Journal of Pharmacology·G WegenerR Rosenberg

Lack of neuronal NOS has consequences for the expression of POMC and POMC-derived peptides in the mouse pituitary

Nov 10, 2001·Acta histochemica·G KeilhoffH G Bernstein

NMDA receptors and the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway are implicated in the antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice

Nov 19, 2013·Journal of Medicinal Food·Andiara E FreitasAna Lúcia S Rodrigues

Effects of intraperitoneally injected lithium, imipramine and diazepam on nitrate levels in rat amygdala

May 18, 2005·Psychiatry and Clinical Neurosciences·Shuji MarutaHitoshi Miyaoka

Antidepressant-like effect of Canavalia brasiliensis (ConBr) lectin in mice: evidence for the involvement of the glutamatergic system

Mar 22, 2014·Pharmacology, Biochemistry, and Behavior·Débora K RiegerRodrigo B Leal

Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of l-arginine-NO-cGMP pathway and BDNF levels

Apr 9, 2014·Brain Research Bulletin·Franciele DonatoCristiano Ricardo Jesse

Nitric oxide production and monoamine oxidase activity in cancer patients during interferon-alpha therapy

Oct 28, 2008·Amino Acids·Durk FekkesGerrit Stoter

Protective effects of ascorbic acid on behavior and oxidative status of restraint-stressed mice.

Oct 12, 2012·Journal of Molecular Neuroscience : MN·Morgana MorettiAna Lúcia S Rodrigues

Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties

Dec 3, 2014·Life Sciences·Anzelle DelportJacobus P Petzer

Developmental nicotine exposure induced alterations in behavior and glutamate receptor function in hippocampus.

Oct 29, 2011·Cellular and Molecular Life Sciences : CMLS·Kodeeswaran ParameshwaranVishnu Suppiramaniam

17α-ethinyl estradiol attenuates depressive-like behavior through GABAA receptor activation/nitrergic pathway blockade in ovariectomized mice

Feb 18, 2016·Psychopharmacology·Seyed Soheil Saeedi SaraviAhmad Reza Dehpour

Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation

Jan 20, 2016·Molecular Psychiatry·M M HarrazS H Snyder

Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways

Jun 30, 2012·Behavioural Brain Research·Luis E B BettioAna Lúcia S Rodrigues

Involvement of NO/cGMP pathway in the antidepressant-like effect of gabapentin in mouse forced swimming test

Jan 13, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Sattar OstadhadiAhmadReza Dehpour

Invited review: the evolution of antidepressant mechanisms

Jan 30, 2004·Fundamental & Clinical Pharmacology·D A SlatteryD J Nutt

Glutamate and depression: clinical and preclinical studies

Dec 20, 2003·Annals of the New York Academy of Sciences·Ian A Paul, Phil Skolnick

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