Nitric oxide synthase-mediated sub-chronic injury and recovery in the small intestine of mice after oral administration with halloysite nanotubes

Environmental Science and Pollution Research International
Tingting HuXiaolong Xu

Abstract

Natural halloysite nanotubes (HNTs) with a hollow lumen have been widely applied in many fields, such as water purification, drug carriers, cosmetics, antibacterial, and scaffolds for tissue engineering. However, their in vivo toxicity is still largely unclear. The aim of this study is to evaluate sub-chronic oral toxicity of HNTs in the small intestine of mice. The results demonstrated that oral HNTs at low dose (5 mg/kg) for 30 days promoted mouse growth with no obvious adverse effect on the small intestine. The promotive effect on mouse growth disappeared after cessation of oral administration of HNTs. Oral HNTs at high dose (50 mg/kg) for 30 days induced aluminum (Al) and silicon (Si) accumulation and oxidative stress in the small intestine, which caused significant increases in the levels of cyclooxygenase-2 (COX-2) and nitric oxide synthase (iNOS) and inflammatory response and iNOS-mediated damages in the organ. Oral HNTs-induced changes in the small intestine at high dose were not observed after a 30-day recovery period. These findings provided the first evidence that oral HNTs-induced sub-chronic toxicity in the small intestine was reversible. The results suggest that HNTs at low concentration in environments have no ad...Continue Reading

References

Feb 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takashi KuwanoMayumi Ono
Dec 13, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Dale W PorterVincent Castranova
Feb 23, 2010·Biomacromolecules·Viviana VergaroStefano Leporatti
Mar 31, 2011·Journal of Nanoscience and Nanotechnology·Y J SuhD Mongayt
Jul 27, 2011·Environmental Toxicology and Pharmacology·Rong ZhangYikai Zhou
Jan 1, 2010·Nano Reviews·Neenu SinghShareen H Doak
Jan 18, 2012·Nanotechnology·Rachel D WhiteFrank C Walsh
Jan 8, 2013·Chemical Communications : Chem Comm·Svetlana A KonnovaRawil F Fakhrullin
Nov 15, 2013·International Journal of Biomedical Nanoscience and Nanotechnology·Ingrid L Bergin, Frank A Witzmann
Jul 9, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mehrosadat AlaviMohammad Atefi
Aug 5, 2015·Colloids and Surfaces. B, Biointerfaces·Farrukh Rafiq AhmedAhsana Dar
Feb 27, 2016·Environmental Toxicology and Chemistry·Lorenza BellaniMarina Massaro
Apr 26, 2016·Journal of Biochemical and Molecular Toxicology·Mohamed M A HusseinMona M Ahmed
May 26, 2015·Nanomaterials·Giuseppe Chichiriccò, Anna Poma
May 11, 2017·International Journal of Pharmaceutics·Salma El-Sayed RadwanAmal Hassan El-Kamel
Aug 14, 2018·Regulatory Toxicology and Pharmacology : RTP·Asghar Ashrafi HafezAhmad Salimi
Aug 9, 2019·Environmental Science and Pollution Research International·Mohamed M A HusseinIslam M Saadeldin
Apr 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mingxian LiuChangren Zhou

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