PMID: 7538022Jan 1, 1995Paper

Nitric oxide synthases: biochemical and molecular regulation

Current Opinion in Nephrology and Hypertension
Y Wang, P A Marsden

Abstract

Nitric oxide synthases are a family of complex cytochrome P450-like hemeproteins that catalyze the five-electron oxidation of L-arginine to form nitric oxide. Nitric oxide synthase apoenzyme is dependent on molecular oxygen, nicotinamide adenine dinucleotide phosphate hydrogen, flavins and tetrahydrobiopterin, and it functions as a dimer. Three human nitric oxide synthase isoforms have been identified to date. The endothelial constitutive, neuronal, and inducible nitric oxide synthase isoforms are found on human chromosomes 7, 12 and 17, respectively. Characterization of the structural organization of the human nitric oxide synthase genes reveals that, although they are structurally related, the mechanisms by which they are regulated are distinct. Expression of the mRNA for endothelial constitutive nitric oxide synthase is regulated at the level of transcription and mRNA stability. The mRNA transcripts derived from the neuronal nitric oxide synthase gene are characterized by a remarkable degree of structural diversity. Levels of inducible nitric oxide synthase mRNA are controlled by interacting combinations of cytokines and biological mediators at the level of gene transcription and mRNA stability.

Citations

Jul 12, 2005·Urological Research·Viswanathan PragasamPalaninathan Varalakshmi
May 14, 2009·Archives of Virology·Zhan-Yong WeiBao-An Cui
Jun 20, 2001·Brain Research. Developmental Brain Research·H TeradaK Kitahama
Feb 24, 2000·International Journal of Immunopharmacology·A S Heiman, D Allen-Gipson
Feb 22, 2001·Animal Reproduction Science·V D Dixit, N Parvizi
Nov 5, 1997·Journal of Pain and Symptom Management·M Anbar, B M Gratt
Jan 1, 1997·Trends in Cardiovascular Medicine·K Sase, T Michel
Jun 29, 2010·Acta Pharmacologica Sinica·Yuan-chao TuDao-wen Wang
Nov 7, 1998·British Journal of Pharmacology·L LecanuM Plotkine
Sep 29, 1998·The European Journal of Neuroscience·D Levy, D W Zochodne
Jun 2, 1998·Kidney International·B J Ballermann
Mar 13, 2003·Kidney International·Patricia G VallésMaria Rüttler
Oct 16, 1999·Anesthesiology·W SteudelW M Zapol
Nov 1, 2005·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·James W E RushDrew A Graham
Jan 18, 2006·The Japanese Journal of Physiology·Yukiko YasuokaKatsumasa Kawahara
May 1, 2009·Indian Journal of Human Genetics·Sushma PatkarT Padma
Aug 19, 2014·Journal of Atherosclerosis and Thrombosis·Soo Lim, Philip Barter
Feb 22, 2005·Cardiovascular Radiation Medicine·Galal E Nagib El-KilanySahar Hazzaa
Jun 12, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Saeedeh SalimiAhmad Mohebbi
Nov 26, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Priscilla C JaramilloLuis A Salazar
Apr 17, 2008·Journal of Diabetes and Its Complications·Intissar EzzidiWassim Y Almawi
Oct 21, 2015·Communicative & Integrative Biology·Katia AquilanoCiriolo Maria Rosa
Mar 24, 2009·Acta Paediatrica·A G A Brouwers, C M J A Waals-van de Wal
Mar 2, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·C Ichai, C Giunti
Apr 18, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Priscilla C JaramilloLuis A Salazar
Dec 13, 2000·Biochimica Et Biophysica Acta·K Stockklauser-FärberP Rösen
Jan 8, 2013·Biochemical and Biophysical Research Communications·Satoshi KashiwagiPaul L Huang
Dec 11, 1999·Proceedings of the Association of American Physicians·M Noris, G Remuzzi
Sep 18, 1999·Veterinary Pathology·J M FliggerT W Jungi
Nov 13, 2003·Arthritis and Rheumatism·Carlo SalvaraniLuigi Boiardi
Mar 24, 2012·The Journal of Pharmacology and Experimental Therapeutics·Yeonsoo JoeHun Taeg Chung

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