Nitric oxide-synthesizing neurons originating at several different levels innervate rat penis

Neuroscience
S VanhataloS Soinila

Abstract

While the crucial role of neurally produced nitric oxide in mediating penile erection is well established, the understanding of the peripheral neuroanatomy of the nitric oxide-ergic pathways is still incomplete. This study was designed to elucidate further the distribution of nitric oxide synthase, and its relation to the distribution of neuropeptides and tyrosine hydroxylase in all penis-projecting neural pathways. A triple-labelling technique was employed, with the retrograde tracer Fluoro Gold combined with neuropeptide immunohistochemistry and nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase histochemistry, a marker of nitric oxide synthase. The presence within the penis of scattered nerve cell bodies exhibiting NADPH-diaphorase activity was revealed. Most (76%) of the penis-projecting neurons in the major pelvic ganglion exhibited NADPH-diaphorase activity and immunoreactivity to vasoactive intestinal peptide, while none of them contained tyrosine hydroxylase. Sympathetic paravertebral postganglionic neurons, in turn, contained tyrosine hydroxylase, but did not exhibit NADPH-diaphorase activity. In the afferent, sensory neurons projecting to the penis from the dorsal root ganglia, NADPH-diaphorase activity co...Continue Reading

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Citations

Aug 10, 1999·European Journal of Pharmacology·K J Way, J J Reid
Jul 6, 2014·International Neurourology Journal·Junyang JungNa Young Jeong
Aug 23, 2000·Biology of Reproduction·N F Gonzalez-CadavidJ Rajfer
Mar 16, 2002·International Journal of Impotence Research·O SazovaK P Jünemann
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura
Sep 5, 2003·Journal of Andrology·Michael A PaleseArthur L Burnett

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