Nitric oxide treatments as adjuncts to reperfusion in acute myocardial infarction: a systematic review of experimental and clinical studies.

Basic Research in Cardiology
Justin S BiceGary F Baxter

Abstract

Unmodified reperfusion therapy for acute myocardial infarction (AMI) is associated with irreversible myocardial injury beyond that sustained during ischemia. Studies in experimental models of ischemia/reperfusion and in humans undergoing reperfusion therapy for AMI have examined potential beneficial effects of nitric oxide (NO) supplemented at the time of reperfusion. Using a rigorous systematic search approach, we have identified and critically evaluated all the relevant experimental and clinical literature to assess whether exogenous NO given at reperfusion can limit infarct size. An inclusive search strategy was undertaken to identify all in vivo experimental animal and clinical human studies published in the period 1990-2014 where NO gas, nitrite, nitrate or NO donors were given to ameliorate reperfusion injury. Articles were screened at title and subsequently at abstract level, followed by objective full text analysis using a critical appraisal tool. In twenty-one animal studies, all NO treatments except nitroglycerin afforded protection against measures of reperfusion injury, including infarct size, creatinine kinase release, neutrophil accumulation and cardiac dysfunction. In three human AMI RCT's, there was no consisten...Continue Reading

Associated Clinical Trials

Dec 20, 2018·Jayshil J. Patel, MD

References

Apr 1, 1995·British Journal of Pharmacology·H BohnK Schönafinger
Jan 5, 1996·The Journal of Biological Chemistry·A M MilesM B Grisham
Jul 27, 1999·Il Farmaco·K Schönafinger
Jul 25, 2000·Circulation Research·G HeuschR Schulz
Feb 1, 2003·European Heart Journal·Frans Van de WerfUNKNOWN Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology
Feb 25, 2003·British Journal of Pharmacology·Péter Ferdinandy, Richard Schulz
Nov 5, 2003·Nature Medicine·Kenyatta CosbyMark T Gladwin
Jan 24, 2004·Circulation Research·Ella S M NgPaul Kubes
Feb 14, 2004·Cardiovascular Research·H M PiperC Schäfer
Apr 17, 2004·Circulation Research·Mark T Gladwin, Alan N Schechter
Sep 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew WebbAmrita Ahluwalia
Apr 21, 2005·The Journal of Clinical Investigation·Mark R DuranskiDavid J Lefer
Jan 31, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ryuji HataishiMarielle Scherrer-Crosbie
Jun 15, 2007·Cardiovascular Research·Cameron DezfulianMark T Gladwin
Aug 8, 2007·The Journal of Experimental Medicine·Sruti ShivaMark T Gladwin
Aug 21, 2007·Journal of the American College of Cardiology·Xiaoshun LiuStefan Janssens
Jul 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ulrike B Hendgen-CottaTienush Rassaf
Sep 18, 2008·Circulation Research·Jonathan S Stamler
Mar 3, 2009·Biochimica Et Biophysica Acta·Claudia PennaPasquale Pagliaro
Apr 17, 2009·The Cochrane Database of Systematic Reviews·Jill FerrariTrevor D Prior
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jan 25, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Yasuko NagasakaKenneth D Bloch
Jun 30, 2011·Journal of Molecular and Cellular Cardiology·Bryan G Schwartz, Robert A Kloner
Sep 21, 2011·The Journal of Biological Chemistry·Tiffany T NguyenElizabeth Murphy
Nov 22, 2011·Antioxidants & Redox Signaling·Erin CurtisSruti Shiva
Jun 2, 2012·Intensive Care Medicine·Nils NeyeWolfgang M Kuebler
May 28, 2013·Nature Medicine·Edward T ChouchaniMichael P Murphy
Jun 19, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Toshihiro ShinboHirosuke Kobayashi
Jul 6, 2013·British Journal of Pharmacology·Tienush RassafRainer Schulz

❮ Previous
Next ❯

Citations

Apr 27, 2016·Pharmacology & Therapeutics·Guanhua DuJuntian Zhang
Jul 1, 2016·Basic Research in Cardiology·Yuliya MikhedAndreas Daiber
Oct 23, 2016·Life Sciences·Fereshte BagheriHamid Khodayari
Jun 27, 2018·European Heart Journal·Manuel Lobo, Borja Ibanez
Jun 26, 2018·Canadian Journal of Physiology and Pharmacology·Xiaohong Tracey Gan, Morris Karmazyn
Dec 24, 2017·Basic Research in Cardiology·Malena MorellMartin Vila Petroff
Sep 20, 2019·Antioxidants·Veani FernandoSaori Furuta
Apr 27, 2017·Cardiovascular Research·Sofia-Iris BibliAndreas Papapetropoulos
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martina Cebova, Olga Pechanova
Apr 14, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Robert T MalletH Fred Downey
Jan 17, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroyuki MinatoYoshimi Inagaki
Apr 19, 2018·Basic Research in Cardiology·Derek M YellonSean M Davidson
Nov 3, 2020·Drug Development Research·Parteek Prasher, Mousmee Sharma
Jan 9, 2021·Free Radical Biology & Medicine·Xiu XuYoujun Yang
Oct 16, 2020·Basic Research in Cardiology·M V BasalayS M Davidson
Feb 19, 2021·Pharmacology & Therapeutics·Kayleigh GriffithsMelanie Madhani
May 16, 2021·British Journal of Pharmacology·Robert LukowskiPeter Ruth
Dec 16, 2020·ACS Biomaterials Science & Engineering·Xinlong ZangXuehong Chen
Aug 28, 2021·International Journal of Molecular Sciences·Wei Sheng SiewWei Hsum Yap

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

PRISMA

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.