Nitric oxide triggers delayed anesthetic preconditioning-induced cardiac protection via activation of nuclear factor-kappaB and upregulation of inducible nitric oxide synthase

Shock
Chen Hsiu ChenJulie Y H Chan

Abstract

Nitric oxide (NO) plays a pivotal role both in triggering and mediating delayed protection against myocardial I/R injury during anesthetic-induced preconditioning (APC). However, the signaling mechanisms that underlie this phenomenon remain unclear. Using isoflurane as a representative anesthetic, the present study tested the hypothesis that NO released after anesthetic-induced preconditioning initiates delayed cardioprotection via activation of nuclear transcription factor-kappaB (NF-kappaB), leading to myocardial adaptation by upregulation of iNOS and increase in production of NO. Sprague-Dawley rats that received open-chest surgery under pentobarbital anesthesia were subject to 30 min of left coronary artery occlusion, followed by 120 min of reperfusion. Exposure to 60 min of 2.1% isoflurane inhalation with oxygen 24 h before ischemia significantly reduced I/R-induced myocardial infarct size that was associated with overexpression of iNOS protein and increased NO content in the heart. These protective effects were abolished by pretreatment with a NOS inhibitor, N-nitro-L-arginine methyl ester, an NF-kappaB blocker, diethyldithiocarbamate, before isoflurane, or a selective iNOS inhibitor, S-methylisothiourea, before left coro...Continue Reading

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Citations

Aug 19, 2008·Shock·Christoph Thiemermann
Nov 15, 2008·Shock·Thiruma V ArumugamTrent M Woodruff
Feb 27, 2009·American Journal of Physiology. Renal Physiology·Tanya M GwathmeyMark C Chappell
Nov 27, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Paul S Pagel, Judith A Hudetz
May 27, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Thorsten M SmulFranz Kehl
Mar 25, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Christopher Lotz, Franz Kehl
Apr 17, 2009·Current Opinion in Anaesthesiology·Stefan G De HertWolfgang S Schlack

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