PMID: 9435634Jan 22, 1998Paper

Nitric oxide triggers late preconditioning against myocardial infarction in conscious rabbits

The American Journal of Physiology
Y QiuRoberto Bolli

Abstract

We tested the hypothesis that late preconditioning (PC) against myocardial infarction is triggered by the formation of nitric oxide (NO). Conscious rabbits underwent a 30-min coronary occlusion followed by 3 days of reperfusion. In group I (control group, n = 10), rabbits were not preconditioned, whereas in group II (n = 10), they were preconditioned 24 h earlier with a sequence of six 4-min occlusion/4-min reperfusion cycles. Myocardial infarct size (tetrazolium staining) was reduced by 50% by PC (28.6 +/- 3.2% of the risk region in group II vs. 56.9 +/- 5.9% in controls, P < 0.05). This reduction in cell death was associated with improved recovery of myocardial function [systolic thickening fraction (by sonomicrometry) at 3 days: 2.0 +/- 11.0% of baseline in group II vs. -20.0 +/- 2.8% in group I, P < 0.05]. Group III rabbits (n = 11) underwent the same protocol as group II except that the rabbits received the NO synthase inhibitor N omega-nitro-L-arginine (L-NNA, 13 mg/kg) before the PC ischemia. In these animals, infarct size did not differ significantly from that observed in control rabbits, indicating that L-NNA completely blocked the development of late PC against myocardial infarction. In group IV (n = 9), rabbits recei...Continue Reading

References

Jun 1, 1992·Circulation·M OvizeR A Kloner
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R Gopalakrishna, W B Anderson
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jan 1, 1995·Annual Review of Physiology·S S Gross, M S Wolin
Oct 1, 1994·Cardiovascular Research·R HaesslerD M Van Winkle
Sep 1, 1996·Circulation Research·R A KellyT W Smith
Jan 1, 1996·Basic Research in Cardiology·M PaulM S Fernandez-Alfonso
Sep 1, 1992·Trends in Cardiovascular Medicine·J M Downey

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Citations

Jul 10, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·O I KukushkinaA A Sosunov
Dec 2, 1998·Basic Research in Cardiology·R BolliJ Zhang
Sep 6, 2005·Cardiovascular Drugs and Therapy·Hani JneidRoberto Bolli
May 25, 2010·Cardiovascular Drugs and Therapy·Derek J Hausenloy, Derek M Yellon
Jun 2, 2007·Heart Failure Reviews·Roberto BolliBuddhadeb Dawn
Mar 28, 2007·Current Heart Failure Reports·Paul B Massion, Jean-Luc Balligand
Feb 18, 2010·Journal of Cardiovascular Translational Research·James A Fallavollita
Feb 24, 2012·The Journal of Physiological Sciences : JPS·Nari YunSun-Mee Lee
Jun 7, 2005·The Journal of Surgical Research·Jeffrey M PitcherDaniel R Meldrum
Dec 5, 2003·Journal of Molecular and Cellular Cardiology·Raúl J DomenechPilar Macho
Jan 13, 2001·The Annals of Thoracic Surgery·J FengE R Rosenkranz
Aug 12, 1999·European Journal of Pharmacology·J C StocletA L Kleschyov
May 10, 2003·Journal of Molecular and Cellular Cardiology·Yu-Ting XuanRoberto Bolli
Feb 20, 2003·The Journal of Surgical Research·Amit BadhwarRichard F Potter
Apr 13, 2000·Pharmacology & Therapeutics·A M Shah, P A MacCarthy
Apr 8, 2003·Journal of the American College of Cardiology·Pier D LambiaseMichael S Marber
Apr 8, 2003·Journal of the American College of Cardiology·Ken ShinmuraRoberto Bolli
Feb 15, 2003·Trends in Cardiovascular Medicine·Roberto BolliYu-Ting Xuan
Oct 17, 2002·Nitric Oxide : Biology and Chemistry·Andrey V GourinePer-Ove Sjöquist
Oct 4, 2000·British Journal of Pharmacology·N YamashitaM Hori
Aug 10, 2000·British Journal of Clinical Pharmacology·R J EdwardsM S Marber
May 25, 2002·Kidney International·Joan TorrasJosep Ma Grinyó
Jan 13, 2000·Proceedings of the Society for Experimental Biology and Medicine·A J Spanier, K H McDonough
Sep 18, 2001·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·T OxmanB Rabinowitz
Mar 18, 2004·Antioxidants & Redox Signaling·Hajime Otani
Feb 11, 2009·Antioxidants & Redox Signaling·Hajime Otani

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