PMID: 6200412Mar 1, 1984

Nitrilotriacetic acid does not induce sister-chromatid exchanges in hamster or human cells

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
S Ved Brat, G M Williams

Abstract

The effect of nitrilotriacetic acid on sister-chromatid exchanges (SCEs) in human peripheral blood lymphocytes and Chinese hamster ovary cells was studied. The chemical did not increase the frequency of SCEs in either cell type. The negative response of these cells supports other evidence that nitrilotriacetic acid is not genotoxic and that its carcinogenicity to the urinary tract may involve an epigenetic mechanism.

References

Apr 1, 1978·Bulletin of Environmental Contamination and Toxicology·I ChuA Viau
Feb 1, 1971·Toxicology and Applied Pharmacology·W R Michael, J M Wakim
Jan 29, 1981·Nature·J Cairns
Nov 11, 1982·Nature·C J TabinE H Chang
Jan 1, 1983·Annals of the New York Academy of Sciences·S Wolff
May 1, 1980·Preventive Medicine·M M Jacobs
Feb 1, 1982·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R L AndersonJ A Merski
Aug 1, 1956·Proceedings of the National Academy of Sciences of the United States of America·S Wolff, H E Luippold

Citations

May 1, 1995·Mutation Research·D ModestiF Degrassi
Dec 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G M WilliamsC Tong
May 1, 1985·Toxicology Letters·M P Grilli, A Capucci
Jan 1, 1985·Environmental Mutagenesis·N LoprienoA G Levis
Jan 1, 1988·Environmental and Molecular Mutagenesis·R CostaA G Levis

Related Concepts

Acetic Acids
Cell Differentiation Process
Cricetulus
Crossing Over, Genetic
Cricetus
Lymphoid Cells
Trisodium Nitrilotriacetate
Ovary
Sister Chromatid Exchange
Staining and Labeling

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