Nitrite and nitrate chemical biology and signalling.

British Journal of Pharmacology
Anthony W DeMartinoMark T Gladwin

Abstract

Inorganic nitrate (NO3 - ), nitrite (NO2 - ) and NO are nitrogenous species with a diverse and interconnected chemical biology. The formation of NO from nitrate and nitrite via a reductive 'nitrate-nitrite-NO' pathway and resulting in vasodilation is now an established complementary route to traditional NOS-derived vasodilation. Nitrate, found in our diet and abundant in mammalian tissues and circulation, is activated via reduction to nitrite predominantly by our commensal oral microbiome. The subsequent in vivo reduction of nitrite, a stable vascular reserve of NO, is facilitated by a number of haem-containing and molybdenum-cofactor proteins. NO generation from nitrite is enhanced during physiological and pathological hypoxia and in disease states involving ischaemia-reperfusion injury. As such, modulation of these NO vascular repositories via exogenously supplied nitrite and nitrate has been evaluated as a therapeutic approach in a number of diseases. Ultimately, the chemical biology of nitrate and nitrite is governed by local concentrations, reaction equilibrium constants, and the generation of transient intermediates, with kinetic rate constants modulated at differing physiological pH values and oxygen tensions. LINKED ART...Continue Reading

Associated Clinical Trials

Sep 9, 2011·Marc A. SimonMarc A. Simon

References

Jan 25, 1975·Journal of Molecular Biology·R Cassoly, Q Gibson
Jun 1, 1992·Journal of Molecular and Cellular Cardiology·U IkedaK Shimada
Jul 1, 1981·Journal of Inorganic Biochemistry·M P Doyle, J W Hoekstra
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroR E Byrns
Jul 12, 1993·FEBS Letters·P C FordD M Stanbury
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·X LiuJ R Lancaster
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·F CutruzzolaM Brunori
May 15, 2001·Acta Physiologica Scandinavica·A ModinJ O Lundberg
Aug 4, 2001·Nitric Oxide : Biology and Chemistry·G ReichenbachC A Palmerini
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·T LauerM Kelm
Jun 25, 2002·Methods in Enzymology·Céline H TaboyAlvin L Crumbliss
Aug 28, 2003·Journal of the American Chemical Society·Bernadette O Fernandez, Peter C Ford
Sep 4, 2003·The Journal of Biological Chemistry·Enika NagababuJoseph M Rifkind
Jan 1, 1962·The American Journal of Physiology·J M ROSSA C GUYTON
Nov 5, 2003·Nature Medicine·Kenyatta CosbyMark T Gladwin
Mar 24, 2004·Micron : the International Research and Review Journal for Microscopy·Djemel HamdaneMichael C Marden
Jun 8, 2004·Inorganic Chemistry·Radu Silaghi-Dumitrescu
Aug 18, 2004·Inorganic Chemistry·Bernadette O FernandezPeter C Ford
Sep 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew WebbAmrita Ahluwalia
Sep 14, 2004·Nature Medicine·Christian J HunterMark T Gladwin
Dec 16, 2004·Journal of Inorganic Biochemistry·Daniel B Kim-ShapiroNeil Hogg
Apr 20, 2005·The Journal of Biological Chemistry·Kris T HuangNeil Hogg
Apr 21, 2005·The Journal of Clinical Investigation·Mark R DuranskiDavid J Lefer
Jun 7, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Anne JeffersDaniel B Kim-Shapiro
Jul 26, 2005·The Journal of Clinical Investigation·Zhi HuangMark T Gladwin
Jun 17, 2006·Journal of Inorganic Biochemistry·Daniel M CopelandGeorge B Richter-Addo
Aug 15, 2006·Nature Chemical Biology·Sruti ShivaMark T Gladwin
Mar 17, 1897·The Journal of Physiology·J HaldaneA E Mavrogordato
Sep 29, 2006·The Journal of Physical Chemistry. a·Gabriel da SilvaBogdan Z Dlugogorski
Dec 13, 2006·Cellular and Molecular Life Sciences : CMLS·A F VaninE E van Faassen
Dec 29, 2006·The New England Journal of Medicine·Filip J LarsenEddie Weitzberg
Feb 20, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Thomas DalsgaardAngela Fago
Feb 27, 2007·The Journal of Biological Chemistry·Rozalina GrubinaMark T Gladwin
Aug 8, 2007·The Journal of Experimental Medicine·Sruti ShivaMark T Gladwin
Aug 19, 2007·IUBMB Life·Celia BonaventuraAlvin L Crumbliss
Sep 4, 2007·American Journal of Physiology. Heart and Circulatory Physiology·T Scott IsbellRakesh P Patel
Nov 6, 2007·Nature Chemical Biology·Swati BasuDaniel B Kim-Shapiro

❮ Previous
Next ❯

Citations

Dec 28, 2019·Antioxidants & Redox Signaling·Jay L Zweier, Govindasamy Ilangovan
Jan 9, 2020·American Journal of Hypertension·Masashi TawaTakaharu Ishibashi
Mar 20, 2020·Expert Opinion on Therapeutic Targets·Biljana Musicki, Arthur L Burnett
Jan 15, 2020·European Cardiology·Amelia Carro, Josefa María Panisello
Dec 18, 2018·British Journal of Pharmacology·Louis J Ignarro
Jul 28, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Fritz-Gerald CharlesBruce D Spiess
Aug 9, 2020·Antioxidants·Karolina Ferysiuk, Karolina M Wójciak
Aug 15, 2019·The Journal of Biological Chemistry·Matías N MöllerBeatriz Alvarez
Nov 12, 2020·Pediatric Research·Jun Kobayashi
Dec 19, 2020·Pulmonary Pharmacology & Therapeutics·Tidarat SriboonyongHarutai Kamalaporn
Nov 3, 2020·Free Radical Biology & Medicine·Sonia R SalvatoreFrancisco J Schopfer
Jul 30, 2020·Nitric Oxide : Biology and Chemistry·Peter C Ford, Katrina M Miranda
Jul 28, 2021·Inorganic Chemistry·Matthew R DentMark T Gladwin
Aug 10, 2021·Nitric Oxide : Biology and Chemistry·Supanat LumbikanandaSirada Srihirun
Sep 10, 2019·Journal of Agricultural and Food Chemistry·Joseph KannerOren Tirosh
Sep 14, 2021·Antioxidants & Redox Signaling·Bo LiAlexander Ryan Lippert
Nov 23, 2021·Antioxidants & Redox Signaling·Jeannette Vasquez-VivarSidhartha Tan
Jan 16, 2022·Nitric Oxide : Biology and Chemistry·Stefan KadachAndrew M Jones

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.